Melanoma is often considered one of the most aggressive and treatment-resistant human
cancers. It is a disease that, due to the presence of melanin pigment, was accurately …

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the
gastrointestinal (GI) tract. They are defined here as KIT (CD117, stem cell factor receptor) …

Context Some melanomas arising from acral, mucosal, and chronically sun-damaged sites
harbor activating mutations and amplification of the type III transmembrane receptor tyrosine …

Purpose Melanomas on mucosal membranes, acral skin (soles, palms, and nail bed), and
skin with chronic sun-induced damage have infrequent mutations in BRAF and NRAS …

Melanoma is a cancer arising from the malignant transformation of melanocytes. These
pigment-producing cells derive embryologically from pluripotent neural crest stem cells …

Melanoma, originating from epidermal melanocytes, is a heterogeneous disease that has
the highest mortality rate among all types of skin cancers. Numerous studies have revealed …

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the
gastrointestinal tract, and they are generally resistant to chemotherapy and radiation …

Gastrointestinal stromal tumor (GIST) is the designation for the specific c-kit expressing and
Kit-signaling driven mesenchymal tumors, many of which have Kit-activating mutations. The …

CD117 (KIT) is a type III receptor tyrosine kinase operating in cell signal transduction in
several cell types. Normally KIT is activated (phosphorylated) by binding of its ligand, the …

Gastrointestinal (GI) stromal tumor (GIST) is the designation for the major subset of GI
mesenchymal tumors and encompasses most tumors previously classified as GI smooth …