Extrinsic noise and heavy-tailed laws in gene expression
Noise in gene expression is one of the hallmarks of life at the molecular scale. Here we
derive analytical solutions to a set of models describing the molecular mechanisms …
derive analytical solutions to a set of models describing the molecular mechanisms …
Age-related epigenetic changes in hippocampal subregions of four animal models of Alzheimer's disease
R Lardenoije, DLA van den Hove, M Havermans… - Molecular and Cellular …, 2018 - Elsevier
Both aging and Alzheimer's disease (AD) are associated with widespread epigenetic
changes, with most evidence suggesting global hypomethylation in AD. It is, however …
changes, with most evidence suggesting global hypomethylation in AD. It is, however …
Information theoretic approaches for inference of biological networks from continuous-valued data
DM Budden, EJ Crampin - BMC systems biology, 2016 - Springer
Background Characterising programs of gene regulation by studying individual protein-DNA
and protein-protein interactions would require a large volume of high-resolution proteomics …
and protein-protein interactions would require a large volume of high-resolution proteomics …
FlexDM: Simple, parallel and fault-tolerant data mining using WEKA
M Flannery, DM Budden, A Mendes - Source code for biology and …, 2015 - Springer
Background With the continued exponential growth in data volume, large-scale data mining
and machine learning experiments have become a necessity for many researchers without …
and machine learning experiments have become a necessity for many researchers without …
Distributed gene expression modelling for exploring variability in epigenetic function
DM Budden, EJ Crampin - BMC bioinformatics, 2016 - Springer
Background Predictive gene expression modelling is an important tool in computational
biology due to the volume of high-throughput sequencing data generated by recent …
biology due to the volume of high-throughput sequencing data generated by recent …
Cautionary tales of inapproximability
Modeling biology as classical problems in computer science allows researchers to leverage
the wealth of theoretical advancements in this field. Despite countless studies presenting …
the wealth of theoretical advancements in this field. Despite countless studies presenting …
Gene expression modelling across multiple cell-lines with MapReduce
DM Budden, EJ Crampin - arXiv preprint arXiv:1507.05720, 2015 - arxiv.org
With the wealth of high-throughput sequencing data generated by recent large-scale
consortia, predictive gene expression modelling has become an important tool for …
consortia, predictive gene expression modelling has become an important tool for …