Bioinspired nanotopographical design of drug delivery systems

JA Finbloom, C Huynh, X Huang… - Nature Reviews …, 2023 - nature.com
Effective drug delivery is important in the treatment of various biomedical conditions, ranging
from autoimmune disorders to cancer and bacterial infections. Nanostructured systems can …

Advanced particulate carrier-mediated technologies for nasal drug delivery

VP Chavda, G Jogi, N Shah, MN Athalye… - Journal of Drug Delivery …, 2022 - Elsevier
Nasal drug delivery has been employed as an alternate and convenient route for the
systemic availability of pharmaceuticals, particularly for potent therapeutics. This is owing to …

Fabrication of chitosan/polyvinylpyrrolidone hydrogel scaffolds containing PLGA microparticles loaded with dexamethasone for biomedical applications

SS Garakani, SM Davachi, Z Bagher… - International journal of …, 2020 - Elsevier
One of the most effective approaches for treatment of chronic rhinosinusitis is the use of
hydrogel scaffolds with the sustained release of a given required drug. With this in mind, first …

Enhancing immunogenicity of antigens through sustained intradermal delivery using chitosan microneedles with a patch-dissolvable design

MC Chen, KY Lai, MH Ling, CW Lin - Acta biomaterialia, 2018 - Elsevier
Reducing the dosage required for vaccination is highly desirable, particularly in cases of
epidemic emergencies. This study evaluated the potential of a chitosan microneedle (MN) …

How to characterize a nasal product. The state of the art of in vitro and ex vivo specific methods

L Salade, N Wauthoz, J Goole, K Amighi - International journal of …, 2019 - Elsevier
Nasal delivery offers many benefits over other conventional routes of delivery (eg oral or
intravenous administration). Benefits include, among others, a fast onset of action, non …

Protein stabilization of ITF2 by NF-κB prevents colitis-associated cancer development

M Lee, YS Kim, S Lim, SH Shin, I Kim, J Kim… - Nature …, 2023 - nature.com
Chronic colonic inflammation is a feature of cancer and is strongly associated with
tumorigenesis, but its underlying molecular mechanisms remain poorly understood …

Mucoadhesive electrospun nanofibers for drug delivery systems: applications of polymers and the parameters' roles

GL Pérez-González, LJ Villarreal-Gómez… - International journal …, 2019 - Taylor & Francis
Electrospun nanofibers have been widely studied for many medical applications. They can
be designed with specific features, including mucoadhesive properties. This review …

Phenylboronic acid-tethered chondroitin sulfate-based mucoadhesive nanostructured lipid carriers for the treatment of dry eye syndrome

G Tan, J Li, Y Song, Y Yu, D Liu, W Pan - Acta biomaterialia, 2019 - Elsevier
Dry eye syndrome is a common eye disease that affects many people worldwide. It is usually
treated with eye drops, which has low bioavailability owing to rapid clearance from the …

[HTML][HTML] DEP-induced ZEB2 promotes nasal polyp formation via epithelial-to-mesenchymal transition

M Lee, S Lim, YS Kim, R Khalmuratova, SH Shin… - Journal of Allergy and …, 2022 - Elsevier
Background Diesel exhaust particles (DEPs) are associated with the prevalence and
exacerbation of allergic respiratory diseases, including allergic rhinitis and allergic asthma …

Sodium hyaluronate/chitosan composite microneedles as a single-dose intradermal immunization system

YH Chiu, MC Chen, SW Wan - Biomacromolecules, 2018 - ACS Publications
Enhancing the immune response to vaccines and minimizing the need for repeated
inoculations remain a challenge in clinical vaccination. This study developed a composite …