DNA methylation in solid tumors: functions and methods of detection

A Martisova, J Holcakova, N Izadi, R Sebuyoya… - International Journal of …, 2021 - mdpi.com
DNA methylation, ie, addition of methyl group to 5′-carbon of cytosine residues in CpG
dinucleotides, is an important epigenetic modification regulating gene expression, and thus …

Cellular and molecular mechanisms implicated in the dual role of ROR2 in cancer

MV Castro, P Lopez-Bergami - Critical Reviews in Oncology/Hematology, 2022 - Elsevier
ROR1 and ROR2 are Wnt receptors that are critical for β-catenin-independent Wnt pathways
and have been linked to processes driving tumor progression, such as cell proliferation …

[HTML][HTML] ROR2 regulates cellular plasticity in pancreatic neoplasia and adenocarcinoma

S Benitz, A Steep, M Nasser, J Preall, UM Mahajan… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Cellular plasticity is a hallmark of pancreatic ductal adenocarcinoma (PDAC) starting from
the conversion of normal cells into precancerous lesions to the progression of carcinoma …

Synthesis, spectral characterization and biological activities of Ag (I), Pt (IV) and Au (III) complexes with novel azo dye ligand (N, N, O) derived from 2-amino-6 …

HAK Kyhoiesh, KJ Al-Adilee - Chemical Papers, 2022 - Springer
Abstract The novel ligand 2-[2'-(6-methoxybenzothiazolyl) azo]-3, 5-dimethyl benzoic acid (6-
MBTAMB), derived from 2-amino-6-methoxy benzothiazole, has been used to synthesize a …

Integrated network pharmacology, transcriptomics, and metabolomics analysis to reveal the mechanism of salt Eucommiae cortex in the treatment of chronic kidney …

J Shen, Y Liu, Q Wang, H Chen, Y Hu, X Guo… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance The skeletal complications associated with chronic kidney
diseases from stages 3–5 in individuals are called Chronic Kidney Disease-Mineral Bone …

Receptor tyrosine kinase-like orphan receptors ROR1/2: Insights into the mechanism of action, inhibition, and therapeutic potential

V Rustagi, G Nagar, P Mittal, A Singh, IK Singh - Protein Kinase Inhibitors, 2022 - Elsevier
Targeted molecular therapy provides a new opportunity for treating different types of
cancers. Cellular protein expression is vital for such targeted therapies. Receptor tyrosine …