Small-molecule prodrugs have become the main toolbox to improve the unfavorable
physicochemical properties of potential therapeutic compounds in contemporary anti-cancer …

Bioorthogonal chemistry refers to any chemical reactions that can occur inside of living
systems without interfering with native biochemical processes, which has become a …

Nanomedicines have been regarded as a potential approach in the field of cancer treatment
due to their unique advantages. Although improved therapeutic efficacy can be achieved …

Camptothecin (CPT) is a cytotoxic alkaloid that attenuates the replication of cancer cells via
blocking DNA topoisomerase 1. Despite its encouraging and wide-spectrum antitumour …

Polyphosphoesters (PPEs) are a class of (bio) degradable polymers with high chemical
versatility and functionality. In particular, water-soluble PPEs with the phosphoester group in …

Camptothecin (CPT) is a highly cytotoxic molecule with excellent antitumor activity against
various cancers. However, its clinical application is severely limited by poor water solubility …

A novel nanodrug delivery system (NDDS) based on block copolymers of Poly (DEA)-block-
Poly (PgMA)(PDPP) was developed to enhance in vitro cellular uptake and anticancer …

The formation of polymeric micelles in aqueous environments through the self-assembly of
amphiphilic polymers can provide a versatile platform to increase the solubility and …

Supramolecular prodrug vesicles with efficient property for dual chemotherapy have been
successfully constructed based on the orthogonal self-assembly between a water-soluble …

Aliphatic polycarbonates (APCs) are promising biocompatible and degradable polymers
with immense potential for biomedical applications. However, current synthetic approaches …