Epigenetic modifications, including those on DNA and histones, have been shown to
regulate cellular metabolism by controlling expression of enzymes involved in the …

The non-enzymatic glycosylation or non-enzymatic covalent modifications (NECMs) or
glycation of cellular proteins result in the generation and accumulation of advanced …

The diversity and dynamics of proteins play essential roles in maintaining the basic
constructions and functions of cells. The abundance of functional proteins is regulated by the …

Because of their long half-lives and highly nucleophilic tails, histones are particularly
susceptible to accumulating nonenzymatic covalent modifications, such as glycation. The …

Due to the lack of suitable chemical tools, probing the protein‐specific glycation is highly
challenging. Herein, we present a strategy based on glycation chemical reporter and …

Ever increasing information on genome and proteome has offered fascinating details and
new opportunities to understand the molecular biology. It is now known that histone proteins …

Protein arginine methylation is a widespread post-translational modification (PTM) in
eukaryotic cells. This chemical modification in proteins functionally modulates diverse …

Background Exposure to glyoxal, the smallest dialdehyde, is associated with several
diseases; humans are routinely exposed to glyoxal because of its ubiquitous presence in …

Comprehensive Summary Functional proteomics is a powerful approach to globally
investigate protein functions and their biological significance. Activity‐based protein profiling …

Fig. 1). 6, 11–14 Similarly, the numbers of lysine methylation sites follows the order of
monomethyllysine 4 dimethyllysine 4 trimethyllysine (eg, 4273 MMK sites, 533 DMK sites …