Cells acquire their ultimate identities by activating combinations of transcription factors that
initiate and sustain expression of the appropriate cell type-specific genes. T cell …

ETS-related gene (ERG) is a member of the E-26 transformation-specific (ETS) family of
transcription factors with roles in development that include vasculogenesis, angiogenesis …

Reconstruction of the molecular pathways controlling organ development has been
hampered by a lack of methods to resolve embryonic progenitor cells. Here we describe a …

The oncogenic transcription factor TAL1/SCL is aberrantly expressed in over 40% of cases
of human T cell acute lymphoblastic leukemia (T-ALL), emphasizing its importance in the …

As early T cell precursors transition from multipotentiality to T lineage commitment, they
change expression of multiple transcription factors. It is unclear whether individual …

The rate at which cells enter the T cell pathway depends not only on the immigration of
hematopoietic precursors into the strong Notch signaling environment of the thymus but also …

The clustered homeobox proteins play crucial roles in development, hematopoiesis, and
leukemia, yet the targets they regulate and their mechanisms of action are poorly …

Individuals with Down syndrome (DS; also known as trisomy 21) have a markedly increased
risk of leukemia in childhood but a decreased risk of solid tumors in adulthood. Acquired …

T-cell acute lymphoblastic leukemia (T-ALL) is a heterogeneous group of hematological
tumors composed of distinct subtypes that vary in their genetic abnormalities, gene …

Oncogenic subtypes in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
are used for risk stratification. However, a significant number of BCP-ALL patients are still …