Multiple drug resistance (MDR), referring to the resistance of cancer cells to a broad
spectrum of structurally and mechanistically unrelated drugs across membranes, severely …

Highlights•The most common reason for the failure of the cancer treatment is the evolving
drug resistance.•The ABC transporters mainly P-gp, BCRP and MRP1 are responsible for …

ATP-binding cassette (ABC) transporters represent one of the largest and oldest families of
membrane proteins in all extant phyla from prokaryotes to humans, which couple the energy …

Drug resistance develops in nearly all patients with colon cancer, leading to a decrease in
the therapeutic efficacies of anticancer agents. This review provides an up-to-date summary …

Resistance to chemotherapy remains one of the most significant obstacles to successful
cancer treatment. While inhibiting drug efflux mediated by ATP-binding cassette (ABC) …

The ATP-binding cassette (ABC) transporters are members of a protein superfamily that are
known to translocate various substrates across membranes, including metabolic products …

Non-small cell lung cancer (NSCLC) is a common diagnosed cancer disease worldwide and
its management remains a challenge. Synergistic cancer therapeutic strategy is interesting …

Multidrug resistance (MDR) triggered by ATP binding cassette (ABC) transporter such as
ABCB1, ABCC1, ABCG2 limited successful cancer chemotherapy. Unfortunately, no …

Cancer, a major public health problem, is one of the world's top leading causes of death.
Common treatments for cancer include cytotoxic chemotherapy, surgery, targeted drugs …

Background Chemotherapy has been widely used to treat cancer, but the appearance of
multidrug resistance (MDR) is the biggest obstacle to successful chemotherapy. One of the …