Single-cell RNA sequencing (scRNA-seq) identifies cell subpopulations within tissue but
does not capture their spatial distribution nor reveal local networks of intercellular …

Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells
in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that …

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome
resistance to immune checkpoint inhibitors in patients with refractory melanoma; however …

Loss of functional β-cell mass is the key mechanism leading to the two main forms of
diabetes mellitus—type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) …

A holistic understanding of tissue and organ structure and function requires the detection of
molecular constituents in their original three-dimensional (3D) context. Imaging mass …

Spatial omics technologies generate wealthy but highly complex datasets. Here we present
Spatial Omics DataBase (SODB), a web-based platform providing both rich data resources …

Single-cell analyses have revealed extensive heterogeneity between and within human
tumours,,–, but complex single-cell phenotypes and their spatial context are not at present …

Melanoma is an immunogenic cancer with a high response rate to immune checkpoint
inhibitors (ICIs). It harbors a high mutation burden compared with other cancers and, as a …

Genomic alterations shape cell phenotypes and the structure of tumor ecosystems in poorly
defined ways. To investigate these relationships, we used imaging mass cytometry to …

Summary Type 1 diabetes (T1D) is widely considered to result from the autoimmune
destruction of insulin-producing β cells. This concept has been a central tenet for decades of …