Neurodegenerative diseases (NDs) are a wide class of disorders of the central nervous
system (CNS) with unknown etiology. Several factors were hypothesized to be involved in …

Fibro-adipogenic progenitors (FAPs) are typically activated in response to muscle injury, and
establish functional interactions with inflammatory and muscle stem cells (MuSCs) to …

Amyotrophic lateral sclerosis (ALS) is the most common form of human motor neuron
disease. It is characterized by the progressive degeneration of upper and lower motor …

Abstract Background Phelan–McDermid syndrome (PMS) is a neurodevelopmental disorder
characterized by developmental delay, intellectual disability, and autistic-like behaviors and …

Parkinson's disease (PD) is a multifactorial disorder characterized by progressive loss of
dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) and the presence …

Dysregulation of mTOR complex 1 (mTORC1) activity drives neuromuscular junction (NMJ)
structural instability during aging; however, downstream targets mediating this effect have …

Amyotrophic lateral sclerosis is a fatal disease resulting from motor neuron degeneration in
the cortex and spinal cord. Cortical hyperexcitability is a hallmark feature of amyotrophic …

Oxidative stress-induced damage is a major mechanism in the pathophysiology of
amyotrophic lateral sclerosis (ALS). A recent human clinical trial showed that the …

Since NLRP3 inflammasome plays a pivotal role in several neurodegenerative disorders,
we hypothesized that levels of inflammasome components could help in diagnosis or …

Activity-dependent neuroprotective protein (ADNP), essential for brain formation, was
discovered as a leading de novo mutated gene causing the autism-like ADNP syndrome …