Ototoxicity is one of the major side-effects of platinum-based chemotherapy, in particular
cisplatin (cis-diammine dichloroplatinum II). To our knowledge, no systematic review has …

Peripheral vestibular disease can be treated with several approaches (eg, maneuvers,
surgery, or medical approach). Comorbidity is common in elderly patients, so polytherapy is …

Spatio-temporal information about head orientation and movement is fundamental to the
sense of balance and motion. Hair cells (HCs) in otolith organs of the vestibular system …

The clinical diagnosis of Parkinson's disease (PD) is very difficult, especially in the early
stage of the disease, because there is no physiological indicator that can be referenced …

Lateral olivocochlear (LOC) efferent neurons modulate auditory nerve fiber (ANF) activity
using a large repertoire of neurotransmitters, including dopamine (DA) and acetylcholine …

The zebrafish lateral line is an established model for hair cell organ damage, yet few studies
link mechanistic disruptions to changes in biologically relevant behavior. We used larval …

Inter-individual behavioral variation is thought to increase fitness and aid adaptation to
environmental change, but the underlying mechanisms are poorly understood. We find that …

The vertebrate diencephalic A11 system provides the sole dopaminergic innervation of
hindbrain and spinal cord and has been implicated in modulation of locomotion and sensory …

Abstract Analysis of mechanotransduction among ensembles of sensory hair cells in vivo is
challenging in many species. To overcome this challenge, we used optical indicators to …

Sensorineural hearing loss is the most common form of hearing loss in humans, and results
from either dysfunction in hair cells, the sensory receptors of sound, or the neurons that …