[HTML][HTML] Mammalian transient receptor potential TRPA1 channels: from structure to disease
K Talavera, JB Startek, J Alvarez-Collazo… - Physiological …, 2020 - journals.physiology.org
The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …
cation channels remarkably conserved through the animal kingdom. Mammals have only …
The role of transient receptor potential vanilloid 1 in common diseases of the digestive tract and the cardiovascular and respiratory system
Q Du, Q Liao, C Chen, X Yang, R Xie, J Xu - Frontiers in Physiology, 2019 - frontiersin.org
Transient receptor potential vanilloid subtype 1 (TRPV1), a member of the transient receptor
potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely …
potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely …
[HTML][HTML] A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment
A Balestrini, V Joseph, M Dourado, RM Reese… - Journal of Experimental …, 2021 - rupress.org
Despite the development of effective therapies, a substantial proportion of asthmatics
continue to have uncontrolled symptoms, airflow limitation, and exacerbations. Transient …
continue to have uncontrolled symptoms, airflow limitation, and exacerbations. Transient …
Forced expiration measurements in mouse models of obstructive and restrictive lung diseases
FC Devos, A Maaske, A Robichaud, L Pollaris… - Respiratory …, 2017 - Springer
Background Pulmonary function measurements are important when studying respiratory
disease models. Both resistance and compliance have been used to assess lung function in …
disease models. Both resistance and compliance have been used to assess lung function in …
Neuronal regulation of immunity in the skin and lungs
KJ Blake, XR Jiang, IM Chiu - Trends in Neurosciences, 2019 - cell.com
The nervous and immune systems are classically studied as two separate entities. However,
their interactions are crucial for maintaining barrier functions at tissues constantly exposed to …
their interactions are crucial for maintaining barrier functions at tissues constantly exposed to …
The emerging role of transient receptor potential channels in chronic lung disease
MG Belvisi, MA Birrell - European Respiratory Journal, 2017 - Eur Respiratory Soc
Chronic lung diseases such as asthma, chronic obstructive pulmonary disease and
idiopathic pulmonary fibrosis are a major and increasing global health burden with a high …
idiopathic pulmonary fibrosis are a major and increasing global health burden with a high …
Diisocyanates influence models of atopic dermatitis through direct activation of TRPA1
We recently used EPA databases to identify that isocyanates, most notably toluene
diisocyanate (TDI), were the pollutant class with the strongest spatiotemporal and …
diisocyanate (TDI), were the pollutant class with the strongest spatiotemporal and …
Polyhexamethylene guanidine aerosol triggers pulmonary fibrosis concomitant with elevated surface tension via inhibiting pulmonary surfactant
X Li, J Zhang, C Du, Y Jiang, W Zhang, S Wang… - Journal of Hazardous …, 2021 - Elsevier
Environmental chemicals inhalation exposure could induce pulmonary fibrosis, which is
characterized by the excessive proliferation of fibroblasts and accumulation of extracellular …
characterized by the excessive proliferation of fibroblasts and accumulation of extracellular …
TRPs in tox: involvement of transient receptor potential-channels in chemical-induced organ toxicity—a structured review
D Steinritz, B Stenger, A Dietrich, T Gudermann… - Cells, 2018 - mdpi.com
Chemicals can exhibit significant toxic properties. While for most compounds, unspecific cell
damaging processes are assumed, a plethora of chemicals exhibit characteristic odors …
damaging processes are assumed, a plethora of chemicals exhibit characteristic odors …
Innate lymphoid cells are required to induce airway hyperreactivity in a murine neutrophilic asthma model
AC Jonckheere, SF Seys, B Steelant… - Frontiers in …, 2022 - frontiersin.org
Rationale Non-allergic asthma is driven by multiple endotypes of which neutrophilic and
pauci-granulocytic asthma have been best established. However, it is still puzzling what …
pauci-granulocytic asthma have been best established. However, it is still puzzling what …