The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

Transient receptor potential vanilloid subtype 1 (TRPV1), a member of the transient receptor
potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely …

Despite the development of effective therapies, a substantial proportion of asthmatics
continue to have uncontrolled symptoms, airflow limitation, and exacerbations. Transient …

Background Pulmonary function measurements are important when studying respiratory
disease models. Both resistance and compliance have been used to assess lung function in …

The nervous and immune systems are classically studied as two separate entities. However,
their interactions are crucial for maintaining barrier functions at tissues constantly exposed to …

Chronic lung diseases such as asthma, chronic obstructive pulmonary disease and
idiopathic pulmonary fibrosis are a major and increasing global health burden with a high …

We recently used EPA databases to identify that isocyanates, most notably toluene
diisocyanate (TDI), were the pollutant class with the strongest spatiotemporal and …

Environmental chemicals inhalation exposure could induce pulmonary fibrosis, which is
characterized by the excessive proliferation of fibroblasts and accumulation of extracellular …

Chemicals can exhibit significant toxic properties. While for most compounds, unspecific cell
damaging processes are assumed, a plethora of chemicals exhibit characteristic odors …

Rationale Non-allergic asthma is driven by multiple endotypes of which neutrophilic and
pauci-granulocytic asthma have been best established. However, it is still puzzling what …