Malaria is the most deadly parasitic disease, affecting hundreds of millions of people
worldwide. Malaria parasites have been associated with their hosts for millions of years …

The efficacious detection of pathogens and prompt induction of innate immune signaling
serve as a crucial component of immune defense against infectious pathogens. Over the …

Epstein-Barr virus infection of B lymphocytes elicits diverse host responses via well-adapted
transcriptional control dynamics. Consequently, this host-pathogen interaction provides a …

Cyclic GMP-AMP synthase (cGAS) binds to microbial and self-DNA in the cytosol and
synthesizes cyclic GMP-AMP (cGAMP), which activates stimulator of interferon genes …

Background Hepatocellular carcinoma (HCC) is among the most common and malignant
cancers with no effective therapeutic approaches. Echinacoside (ECH), a phenylethanoid …

Type I interferons (IFN-Is) are important cytokines playing critical roles in various infections,
autoimmune diseases, and cancer. Studies have also shown that IFN-Is exhibit …

Abstract Membrane‐associated RING‐CH (MARCH) family proteins were recently reported
to inhibit viral replication through multiple modes. Previous work showed that human …

Targeted protein degradation (TPD) is emerging as one of the most innovative strategies to
tackle infectious diseases. Particularly, proteolysis-targeting chimera (PROTAC)-mediated …

Stringent control of the type I interferon (IFN-I) signaling is critical for host immune defense
against infectious diseases, yet the molecular mechanisms that regulate this pathway …

Olfactory receptors (Olfr) are G protein–coupled receptors that are normally expressed on
olfactory sensory neurons to detect volatile chemicals or odorants. Interestingly, many Olfrs …