Under physiological and pathological conditions, cells activate the unfolded protein
response (UPR) to deal with the accumulation of unfolded or misfolded proteins in the …

The combined derangements in mitochondria network, function and dynamics can affect
metabolism and ATP production, redox homeostasis and apoptosis triggering, contributing …

The transcription factor, forkhead box M1 (FOXM1), has been implicated in the natural
history and outcome of newly diagnosed high-risk myeloma (HRMM) and relapsed/refractory …

Multiple myeloma (MM), the second most common hematologic malignancy, is an incurable
disease characterized by the accumulation of malignant plasma cells within the bone …

Abstract 5′ adenosine monophosphate–activated protein kinase–related kinase 5 (ARK5)
is involved in mitochondrial ATP production and associated with poor prognosis of multiple …

Iron plays a major role in multiple processes involved in cell homeostasis such as
metabolism, respiration and DNA synthesis. Cancer cells exhibit pronounced iron retention …

Multiple myeloma (MM) is a B-cell malignancy requiring inflammatory microenvironment
signals for cell survival and proliferation. Despite improvements in pharmacological tools …

Multiple myeloma (MM) is a plasma cell dyscrasia characterized by the clonal proliferation of
antibody producing plasma cells. Despite the use of next generation proteasome inhibitors …

Metabolic changes of malignant plasma cells (PCs) and adaptation to tumour
microenvironment represent one of the hallmarks of multiple myeloma (MM). We previously …

Relapse in multiple myeloma (MM) decreases therapy efficiency through unclear
mechanisms of chemoresistance. Since our group previously demonstrated that heme …