Antibody directed enzyme prodrug therapy has the potential to be an effective therapy for
most common solid cancers. Clinical studies with CPG2 system have shown the feasibility of …

Microbial enzymes are crucial catalysts in various industries due to their versatility and
efficiency. The microbial enzymes market has recently expanded due to increased demand …

Thymoquinone (2-methyl-5-propan-2-ylcyclohexa-2, 5-diene-1, 4-dione; TQ), a principal
bioactive phytoconstituent of Nigella sativa essential oil, has been reported to have high …

Nitroreductases, enzymes found mostly in bacteria and also in few eukaryotes, use
nicotinamide adenine dinucleotide (NADH) or nicotinamide adenine dinucleotide phosphate …

Due to its severe burden and geographic distribution, Chagas disease (CD) has a significant
social and economic impact on low-income countries. Benznidazole and nifurtimox are …

Nitroreductases (NRs) hold promise for converting nitroaromatics to aromatic amines.
Nitroaromatic reduction rate increases with Hammett substituent constant for NRs from two …

Widely used in multiple industrial processes, nitro-aromatic compounds, especially
nitrobenzene, in low temperature environment are considered as heavy pollutants. Among …

Objectives Nitrofurantoin is recommended as first-line therapy for the optimal treatment of
uncomplicated urinary tract infections (UTIs) caused by enterococci and Escherichia coli …

Directed enzyme prodrug therapy is a chemotherapy strategy that utilises prodrug-activating
enzymes to activate prodrugs at the tumour location, thus reducing off-target effects. The …

Abstract A NADPH-dependent and FMN-containing nitroreductase (Gox0834) from
Gluconobacter oxydans was cloned and heterogeneously expressed in Escherichia coli …