Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm and was the first
neoplastic disease associated with a well-defined genotypic anomaly―the presence of the …

Human karyotype is usually studied by classical cytogenetic (banding) techniques. To
perform it, one has to obtain metaphase chromosomes of mitotic cells. This leads to the …

Abstract Objective and Background Chronic myeloid leukemia (CML) is a neoplastic disease
whose genetic and cytogenetic changes play important roles in prognosis and treatment …

C3G (Crk SH3-domain-binding guanine-nucleotide-releasing factor) is a ubiquitously
expressed member of a class of molecules called GEFs (guanine-nucleotide-exchange …

Simple Summary Chronic myeloid leukemia (CML) is a blood cancer currently well
managed with drugs that inhibit the protein responsible for the disease. However, some …

Abstract Background The t (9; 22)(q34; q11), generating the Philadelphia (Ph) chromosome,
is found in more than 90% of patients with chronic myeloid leukemia (CML). As a result of …

Background Chronic myelogenous leukemia (CML) results from the neoplastic
transformation of a haematopoietic stem cell. The hallmark genetic abnormality of CML is a …

Background Chronic myeloid leukaemia (CML) is one of the most well characterised human
malignancies. Most patients have a cytogenetically visible translocation between …

Anchored ChromPET, a technique to capture and interrogate targeted sequences in the
genome, has been developed to identify chromosomal aberrations and define breakpoints …

CMTM5 has been shown to exhibit tumor suppressor activities, however, its role in leukemia
is unclear. Herein we firstly reported the expression and function of CMTM5 in myeloid …