Spermatogenesis is the cellular process by which spermatogonia develop into mature
spermatids within seminiferous tubules, the functional unit of the mammalian testis, under …

Sertoli cells are somatic cells present in seminiferous tubules which have essential roles in
regulating spermatogenesis. Considering that each Sertoli cell is able to support a limited …

Gap junctions are essential to the function of multicellular animals, which require a high
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …

The complex morphology of the Sertoli cells and their interactions with germ cells has been
a focus of investigators since they were first described by Enrico Sertoli. In the past 50 years …

Thyroid hormone is a critical regulator of growth, development and metabolism in virtually all
tissues, and altered thyroid status affects many organs and systems. Although for many …

Gap junctions (GJ) and hemichannels (HC) formed from the protein subunits called
connexins are transmembrane conduits for the exchange of small molecules and ions …

The testes produce the male gametes and the male sexual hormones (androgens). The term
spermatogenesis describes and includes all the processes involved in the production of …

The predominant testicular gap junctional protein connexin43 (cx43) is located between
neighboring Sertoli cells (SCs) and between SCs and germ cells. It is assumed to be …

Sox9 and Sox8 are transcription factors expressed in embryonic and postnatal Sertoli cells
of the mouse testis. Sox9 inactivation prior to the sex determination stage leads to complete …

In mammalian testes, the blood–testis barrier (BTB) or Sertoli cell barrier created by
specialized junctions between Sertoli cells near the basement membrane confers an …