Cancer cells establish replicative immortality by activating a telomere-maintenance
mechanism (TMM), be it telomerase or the alternative lengthening of telomeres (ALT) …

The i-motif represents a paradigmatic example of the wide structural versatility of nucleic
acids. In remarkable contrast to duplex DNA, i-motifs are four-stranded DNA structures held …

In addition to the canonical double helix, DNA can fold into various other inter-and
intramolecular secondary structures. Although many such structures were long thought to be …

Telomere maintenance via telomerase reactivation is a nearly universal hallmark of cancer
cells which enables replicative immortality. In contrast, telomerase activity is silenced in most …

G-quadruplexes are four-stranded DNA structures that are over-represented in gene
promoter regions and are viewed as emerging therapeutic targets in oncology, as …

The G-quadruplex is an alternative DNA structural motif that is considered to be functionally
important in the mammalian genome for transcriptional regulation, DNA replication and …

The intriguing structural diversity in folded topologies available to guanine-rich nucleic acid
repeat sequences have made four-stranded G-quadruplex structures the focus of both basic …

G-quadruplex is a non-canonical nucleic acid structure formed by the folding of guanine rich
DNA or RNA. The conformation and function of G-quadruplex are determined by a number …

Guanine-rich DNA sequences can form G-quadruplexes stabilized by stacked G–G–G–G
tetrads in monovalent cation-containing solution. The length and number of individual G …

The 3′‐ends of human chromosomal DNA terminate in short single‐stranded guanine‐rich
tandem‐repeat sequences. In cancer cells, these are associated with the telomere …