Modeling clear cell renal cell carcinoma and therapeutic implications
MM Wolf, W Kimryn Rathmell, KE Beckermann - Oncogene, 2020 - nature.com
Renal cell carcinoma (RCC) comprises a diverse group of malignancies arising from the
nephron. The most prevalent type, clear cell renal cell carcinoma (ccRCC), is characterized …
nephron. The most prevalent type, clear cell renal cell carcinoma (ccRCC), is characterized …
[HTML][HTML] CRISPR: History and perspectives to the future
Z Kozovska, S Rajcaniova, P Munteanu… - Biomedicine & …, 2021 - Elsevier
This review summarizes the information about the history and future of the CRISPR/Cas9
method. Genome editing can be perceived as a group of technologies that allow scientists to …
method. Genome editing can be perceived as a group of technologies that allow scientists to …
ApoC1 promotes the metastasis of clear cell renal cell carcinoma via activation of STAT3
Y Li, L Wu, L Zeng, Z Zhang, W Wang, C Zhang, N Lin - Oncogene, 2020 - nature.com
Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer and frequently
diagnosed at an advanced stage. It is prone to develop unpredictable metastases even with …
diagnosed at an advanced stage. It is prone to develop unpredictable metastases even with …
[PDF][PDF] VHL loss reprograms the immune landscape to promote an inflammatory myeloid microenvironment in renal tumorigenesis
Clear cell renal cell carcinoma (ccRCC) is characterized by dysregulated hypoxia signaling
and a tumor microenvironment (TME) highly enriched in myeloid and lymphoid cells. Loss of …
and a tumor microenvironment (TME) highly enriched in myeloid and lymphoid cells. Loss of …
Application of CRISPR/Cas9 gene editing technique in the study of cancer treatment
C Jiang, L Meng, B Yang, X Luo - Clinical genetics, 2020 - Wiley Online Library
In recent years, gene editing, especially that using clustered regularly interspaced short
palindromic repeat (CRISPR)/Cas9, has made great progress in the field of gene function …
palindromic repeat (CRISPR)/Cas9, has made great progress in the field of gene function …
[HTML][HTML] Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy
Loss-of-function mutations in genes encoding the Krebs cycle enzymes Fumarate Hydratase
(FH) and Succinate Dehydrogenase (SDH) induce accumulation of fumarate and succinate …
(FH) and Succinate Dehydrogenase (SDH) induce accumulation of fumarate and succinate …
Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma
Loss of function of the von Hippel-Lindau (VHL) tumor suppressor gene is a hallmark of
clear cell renal cell carcinoma (ccRCC). The importance of heterogeneity in the loss of this …
clear cell renal cell carcinoma (ccRCC). The importance of heterogeneity in the loss of this …
Endoglin is essential for the maintenance of self-renewal and chemoresistance in renal cancer stem cells
Renal cell carcinoma (RCC) is a deadly malignancy due to its tendency to metastasize and
resistance to chemotherapy. Stem-like tumor cells often confer these aggressive behaviors …
resistance to chemotherapy. Stem-like tumor cells often confer these aggressive behaviors …
CRISPR/Cas9: the Jedi against the dark empire of diseases
Abstract Advances in Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR
associated system (CRISPR/Cas9) has dramatically reshaped our ability to edit genomes …
associated system (CRISPR/Cas9) has dramatically reshaped our ability to edit genomes …
CRISPR-Cas9: a promising genetic engineering approach in cancer research
ZA Ratan, YJ Son, MF Haidere… - … in medical oncology, 2018 - journals.sagepub.com
Bacteria and archaea possess adaptive immunity against foreign genetic materials through
clustered regularly interspaced short palindromic repeat (CRISPR) systems. The discovery …
clustered regularly interspaced short palindromic repeat (CRISPR) systems. The discovery …