Control of synapse development and plasticity by Rho GTPase regulatory proteins
Synapses are specialized cell–cell contacts that mediate communication between neurons.
Most excitatory synapses in the brain are housed on dendritic spines, small actin-rich …
Most excitatory synapses in the brain are housed on dendritic spines, small actin-rich …
Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT–PIX complexes
W Zhou, X Li, RT Premont - Journal of Cell Science, 2016 - journals.biologists.com
The GIT proteins, GIT1 and GIT2, are GTPase-activating proteins (inactivators) for the ADP-
ribosylation factor (Arf) small GTP-binding proteins, and function to limit the activity of Arf …
ribosylation factor (Arf) small GTP-binding proteins, and function to limit the activity of Arf …
The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the βPIX guanine nucleotide exchange factor for Rac1 and …
E Park, M Na, J Choi, S Kim, JR Lee, J Yoon… - Journal of Biological …, 2003 - ASBMB
The Shank/ProSAP family of multidomain proteins is known to play an important role in
organizing synaptic multiprotein complexes. Here we report a novel interaction between …
organizing synaptic multiprotein complexes. Here we report a novel interaction between …
The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo
The cytoskeletal matrix assembled at active zones (CAZ) is implicated in defining
neurotransmitter release sites. However, little is known about the molecular mechanisms by …
neurotransmitter release sites. However, little is known about the molecular mechanisms by …
The role of Rho GTPases and associated kinases in regulating neurite outgrowth
M Nikolic - The international journal of biochemistry & cell biology, 2002 - Elsevier
Neurones are highly specialised cells that can extend over great distances, enabling the
complex networking of the nervous system. We are beginning to understand in detail the …
complex networking of the nervous system. We are beginning to understand in detail the …
KCC2 regulates actin dynamics in dendritic spines via interaction with β-PIX
O Llano, S Smirnov, S Soni, A Golubtsov… - Journal of Cell …, 2015 - rupress.org
Chloride extrusion in mature neurons is largely mediated by the neuron-specific potassium-
chloride cotransporter KCC2. In addition, independently of its chloride transport function …
chloride cotransporter KCC2. In addition, independently of its chloride transport function …
β1PIX, the PAK-interacting exchange factor, requires localization via a coiled-coil region to promote microvillus-like structures and membrane ruffles
PIX is a Rho-family guanine nucleotide exchange factor that binds PAK. We previously
described two isoforms of PIX that differ in their N termini. Here, we report the identification of …
described two isoforms of PIX that differ in their N termini. Here, we report the identification of …
Phosphorylation of p85 βPIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor …
EY Shin, KS Shin, CS Lee, KN Woo, SH Quan… - Journal of Biological …, 2002 - ASBMB
Guanine nucleotide exchange factors (GEFs) have been implicated in growth factor-induced
neuronal differentiation through the activation of small GTPases. Although phosphorylation …
neuronal differentiation through the activation of small GTPases. Although phosphorylation …
A βPix–Pak2a signaling pathway regulates cerebral vascular stability in zebrafish
J Liu, SD Fraser, PW Faloon… - Proceedings of the …, 2007 - National Acad Sciences
The vasculature tailors to the needs of different tissues and organs. Molecular, structural,
and functional specializations are observed in different vascular beds, but few genetic …
and functional specializations are observed in different vascular beds, but few genetic …
Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin
RJ Buchsbaum, BA Connolly, LA Feig - Journal of Biological Chemistry, 2003 - ASBMB
Tiam1 is a ubiquitous guanine nucleotide exchange factor (GEF) that activates the Rac
GTPase. We have shown previously that the N terminus of Tiam1 contributes to the signaling …
GTPase. We have shown previously that the N terminus of Tiam1 contributes to the signaling …