The homochirality of biomolecules in nature, such as DNA, RNA, peptides and proteins, has
played a critical role in establishing and sustaining life on Earth. This chiral bias has also …

Therapeutic antibody drug development is a rapidly growing sector of the pharmaceutical
industry. However, antibody drug development for the brain is a technical challenge, and …

Motivation Antibody-antigen complex modelling is an important step in computational
workflows for therapeutic antibody design. While experimentally determined structures of …

In this study, we generated a novel library approach for high throughput de novo
identification of humanized single-domain antibodies following camelid immunization. To …

Antibody-based therapeutics constitute a rapidly growing class of pharmaceutical
compounds. However, monoclonal antibodies, which specifically engage only one target …

Optimal pharmacokinetic (PK) properties of therapeutic monoclonal antibodies (mAbs) are
essential to achieve the desired pharmacological benefits in patients. To accomplish this, we …

Despite the central role that antibodies play in modern medicine, there is currently no way to
rationally design novel antibodies to bind a specific epitope on a target. Instead, antibody …

Antibody drugs have become a key part of biotherapeutics. Patients suffering from various
diseases have benefited from antibody therapies. However, its development process is …

In the quest to market increasingly safer and more potent biotherapeutic proteins, the
concept of the multi-attribute method (MAM) has emerged from biopharmaceutical …

Abstract mAbs are highly indispensable tools for diagnostic, prophylactic, and therapeutic
applications. The first technique, hybridoma technology, was based on fusion of B …