Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic
B Blasco, D Leroy, DA Fidock - Nature medicine, 2017 - nature.com
The global adoption of artemisinin-based combination therapies (ACTs) in the early 2000s
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …
Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms
D Hughes, DI Andersson - Nature Reviews Genetics, 2015 - nature.com
Drug therapy has a crucial role in the treatment of viral, bacterial, fungal and protozoan
infections, as well as the control of human cancer. The success of therapy is being …
infections, as well as the control of human cancer. The success of therapy is being …
Changing prevalence of potential mediators of aminoquinoline, antifolate, and artemisinin resistance across Uganda
Abstract Background In Uganda, artemether-lumefantrine is recommended for malaria
treatment and sulfadoxine-pyrimethamine for chemoprevention during pregnancy, but drug …
treatment and sulfadoxine-pyrimethamine for chemoprevention during pregnancy, but drug …
Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments—a …
BMC medicine, 2019 - Springer
Background Plasmodium falciparum infections with slow parasite clearance following
artemisinin-based therapies are widespread in the Greater Mekong Subregion. A molecular …
artemisinin-based therapies are widespread in the Greater Mekong Subregion. A molecular …
Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass …
Malaria parasite infection is initiated by the mosquito-transmitted sporozoite stage, a highly
motile invasive cell that targets hepatocytes in the liver for infection. A promising approach to …
motile invasive cell that targets hepatocytes in the liver for infection. A promising approach to …
The genomic architecture of antimalarial drug resistance
AN Cowell, EA Winzeler - Briefings in functional genomics, 2019 - academic.oup.com
Plasmodium falciparum and Plasmodium vivax, the two protozoan parasite species that
cause the majority of cases of human malaria, have developed resistance to nearly all …
cause the majority of cases of human malaria, have developed resistance to nearly all …
Strong positive selection biases identity-by-descent-based inferences of recent demography and population structure in Plasmodium falciparum
Malaria genomic surveillance often estimates parasite genetic relatedness using metrics
such as Identity-By-Decent (IBD), yet strong positive selection stemming from antimalarial …
such as Identity-By-Decent (IBD), yet strong positive selection stemming from antimalarial …
Chloroquine and sulfadoxine–pyrimethamine resistance in Sub-Saharan Africa—A review
Malaria is a great concern for global health and accounts for a large amount of morbidity and
mortality, particularly in Africa, with sub-Saharan Africa carrying the greatest burden of the …
mortality, particularly in Africa, with sub-Saharan Africa carrying the greatest burden of the …
Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial …
Therapeutics with novel modes of action and a low risk of generating resistance are urgently
needed to combat drug-resistant Plasmodium falciparum malaria. Here, we report that the …
needed to combat drug-resistant Plasmodium falciparum malaria. Here, we report that the …
Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance
JL Small-Saunders, LM Hagenah, KJ Wicht… - PLoS …, 2022 - journals.plos.org
Multidrug-resistant Plasmodium falciparum parasites have emerged in Cambodia and
neighboring countries in Southeast Asia, compromising the efficacy of first-line antimalarial …
neighboring countries in Southeast Asia, compromising the efficacy of first-line antimalarial …