The spinal cord receives, relays and processes sensory information from the periphery and
integrates this information with descending inputs from supraspinal centres to elicit precise …

Netrin-1 is upregulated in cancers as a protumoural mechanism. Here we describe netrin-1
upregulation in a majority of human endometrial carcinomas (ECs) and demonstrate that …

The development of a functional nervous system entails establishing connectivity between
appropriate synaptic partners. During axonal pathfinding, the developing axon navigates …

Initiating drug use during adolescence increases the risk of developing addiction or other
psychopathologies later in life, with long-term outcomes varying according to sex and exact …

Netrin-1 is a bifunctional chemotropic guidance cue that plays key roles in diverse cellular
processes including axon pathfinding, cell migration, adhesion, differentiation, and survival …

The Netrin-1/DCC guidance cue pathway plays a critical role in guiding growing axons
toward the prefrontal cortex during adolescence and in the maturational organization and …

Summary The small GTPase Arl13b is enriched in primary cilia and regulates Sonic
hedgehog (Shh) signaling. During neural development, Shh controls patterning and …

BACKGROUND In vertebrates, the central and peripheral nervous system (CNS and PNS,
respectively) are segregated at the cellular level. The CNS encompasses the brain and …

Neurons migrate from their birthplaces to the destinations, and extending axons navigate to
their synaptic targets by sensing various extracellular cues in spatiotemporally controlled …

A morphogen is a signaling molecule that induces specific cellular responses depending on
its local concentration. The concept of morphogenic gradients has been a central paradigm …