[HTML][HTML] Silencing neurons: tools, applications, and experimental constraints

JS Wiegert, M Mahn, M Prigge, Y Printz, O Yizhar - Neuron, 2017 - cell.com
Reversible silencing of neuronal activity is a powerful approach for isolating the roles of
specific neuronal populations in circuit dynamics and behavior. In contrast with neuronal …

Microbial rhodopsins: diversity, mechanisms, and optogenetic applications

EG Govorunova, OA Sineshchekov, H Li… - Annual review of …, 2017 - annualreviews.org
Microbial rhodopsins are a family of photoactive retinylidene proteins widespread
throughout the microbial world. They are notable for their diversity of function, using …

Dynamics and mechanism of a light-driven chloride pump

S Mous, G Gotthard, D Ehrenberg, S Sen, T Weinert… - Science, 2022 - science.org
Chloride transport by microbial rhodopsins is an essential process for which molecular
details such as the mechanisms that convert light energy to drive ion pumping and ensure …

[HTML][HTML] Femtosecond-to-millisecond structural changes in a light-driven sodium pump

P Skopintsev, D Ehrenberg, T Weinert, D James… - Nature, 2020 - nature.com
Light-driven sodium pumps actively transport small cations across cellular membranes.
These pumps are used by microorganisms to convert light into membrane potential and …

Structural insights into ion conduction by channelrhodopsin 2

O Volkov, K Kovalev, V Polovinkin, V Borshchevskiy… - Science, 2017 - science.org
INTRODUCTION Ion channels are integral membrane proteins that upon stimulation
modulate the flow of ions across the cell or organelle membrane. The resulting electrical …

[HTML][HTML] Salinity tolerance in plants. Quantitative approach to ion transport starting from halophytes and stepping to genetic and protein engineering for manipulating …

V Volkov - Frontiers in Plant Science, 2015 - frontiersin.org
Ion transport is the fundamental factor determining salinity tolerance in plants. The Review
starts from differences in ion transport between salt tolerant halophytes and salt-sensitive …

[HTML][HTML] Molecular mechanism of light-driven sodium pumping

K Kovalev, R Astashkin, I Gushchin, P Orekhov… - Nature …, 2020 - nature.com
The light-driven sodium-pumping rhodopsin KR2 from Krokinobacter eikastus is the only
non-proton cation active transporter with demonstrated potential for optogenetics. However …

Inward H+ pump xenorhodopsin: Mechanism and alternative optogenetic approach

V Shevchenko, T Mager, K Kovalev, V Polovinkin… - Science …, 2017 - science.org
Generation of an electrochemical proton gradient is the first step of cell bioenergetics. In
prokaryotes, the gradient is created by outward membrane protein proton pumps. Inward …

Mechanism of transmembrane signaling by sensor histidine kinases

I Gushchin, I Melnikov, V Polovinkin, A Ishchenko… - Science, 2017 - science.org
INTRODUCTION Microorganisms obtain most of the information about their environments
through membrane-associated signaling systems. One of the most abundant classes of …

Structure and mechanisms of sodium-pumping KR2 rhodopsin

K Kovalev, V Polovinkin, I Gushchin, A Alekseev… - Science …, 2019 - science.org
Rhodopsins are the most universal biological light-energy transducers and abundant
phototrophic mechanisms that evolved on Earth and have a remarkable diversity and …