HER2 or ErbB2 is a member of the epidermal growth factor family and is overexpressed in
subsets of breast, ovarian, gastric, colorectal, pancreatic, and endometrial cancers. HER2 …

Introduction: βIII-Tubulin (TUBB3) is predominantly expressed in neurons of the central and
peripheral nervous systems, while in normal non-neoplastic tissues it is barely detectable …

Objectives: Heterogeneity of HER2 gene amplification is found in a subset of breast cancers.
We investigated the impact of HER2 heterogeneity on trastuzumab responses and clinical …

Microtubules are multifunctional cytoskeletal proteins that are involved in crucial cellular
roles including maintenance of cell shape, intracellular transport, meiosis, and mitosis. Class …

Overexpression of class III β‑tubulin (TUBB3), a factor that confers dynamic properties to
microtubules, is a candidate biomarker for resistance to microtubule‑targeting …

The purpose of this study was to investigate, in the context of a prospective node-positive-
breast cancer trial HER2 containing-regimen (UNICANCER-PACS 04 trial), the predictive …

Although trastuzumab is a successful targeted therapy for breast cancer patients with tumors
expressing HER2 (ERBB2), many patients eventually progress to drug resistance. Here, we …

Abstract Trastuzumab-emtansine (T-DM1) is an antibody-drug conjugate that specifically
targets HER2 thanks to its antibody component trastuzumab. In spite of responses to this …

Background Clinical management of locally advanced breast cancer (LABC) is a common
clinical problem. Therefore, finding a good predictor for the efficacy of treatment is crucial …

The subunit protein of microtubules is tubulin, which has been the target for some of the
most successful and widely used anti-tumor drugs. Most of the drugs that target tubulin bind …