DNA supercoiling controls a variety of cellular processes, including transcription,
recombination, chromosome replication, and segregation, across all domains of life. As a …

Simple Summary Mastitis, a common ailment affecting dairy cows, carries significant
economic implications. Common treatments with synthetic antimicrobials face challenges …

BACKGROUND: Increasing evidence suggests that superoxide ions produced by NOX
(nicotinamide adenine dinucleotide phosphate oxidases) mediate vascular effects of Ang II …

Statins, the 3-hydroxy-3-methyl-glutaryl (HMG)-CoA reductase inhibitors, are widely
prescribed for treatment of hypercholesterolemia. Although statins are generally well …

Differential HLA-C levels influence several human diseases, but the mechanisms
responsible are incompletely characterized. Using a validated prediction algorithm, we …

Depending on its stringency, exposure to heat in early life leads to either resilience or
vulnerability to heat stress later in life. We hypothesized that epigenetic alterations in genes …

Background IL-8 is an important chemokine implicated in the pathogenesis of chronic
rhinosinusitis (CRS), but little is known about epigenetic regulation of IL8 in the …

Background Treatment options for hepatocellular carcinoma (HCC) are limited, and overall
survival is poor. Despite the high frequency of this malignoma, its basic disease …

In this review, we decipher findings that identify how epigenetic regulates CD4+ T-cell
functions and the advancement of novel epigenetic mechanisms in systemic lupus …

Background Homeobox genes encode a diverse set of transcription factors implicated in a
vast range of biological processes including, but not limited to, embryonic cell fate …