p16INK4a immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysis
I Tsoumpou, M Arbyn, M Kyrgiou, N Wentzensen… - Cancer treatment …, 2009 - Elsevier
BACKGROUND: P16INK4a is a biomarker for transforming HPV infections that could act as
an adjunct to current cytological and histological assessment of cervical smears and …
an adjunct to current cytological and histological assessment of cervical smears and …
[HTML][HTML] Patient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancer
K Lõhmussaar, R Oka, JE Valle-Inclan, MHH Smits… - Cell Stem Cell, 2021 - cell.com
Cervical cancer is a common gynecological malignancy often caused by high-risk human
papillomavirus. There is a paucity of human-derived culture systems to study the cervical …
papillomavirus. There is a paucity of human-derived culture systems to study the cervical …
Recent advancement of nanomedicine-based targeted delivery for cervical cancer treatment
R Yadav, PP Das, S Sharma, S Sengupta, D Kumar… - Medical Oncology, 2023 - Springer
Cervical cancer is a huge worldwide health burden, impacting women in impoverished
nations in particular. Traditional therapeutic approaches, such as surgery, radiation therapy …
nations in particular. Traditional therapeutic approaches, such as surgery, radiation therapy …
Epigenetic alterations as cancer diagnostic, prognostic, and predictive biomarkers
D Deng, Z Liu, Y Du - Advances in genetics, 2010 - Elsevier
Alterations of DNA methylation and transcription of microRNAs (miRNAs) are very stable
phenomena in tissues and body fluids and suitable for sensitive detection. These …
phenomena in tissues and body fluids and suitable for sensitive detection. These …
p16INK4a and Ki67 expression in normal, dysplastic and neoplastic uterine cervical epithelium and human papillomavirus (HPV) infection
LN Calil, MIA Edelweiss, L Meurer, CN Igansi… - … -Research and Practice, 2014 - Elsevier
Cellular cycle proteins like the p16 INK4a and the Ki67 proliferation nuclear antigen have
been used as oncogenicity cellular markers. The E6 and E7 oncoproteins interact with tumor …
been used as oncogenicity cellular markers. The E6 and E7 oncoproteins interact with tumor …
Frequency and role of HPV in the progression of epithelial dysplasia to oral cancer
F Angiero, LB Gatta, R Seramondi, A Berenzi… - Anticancer …, 2010 - ar.iiarjournals.org
Background: Human papillomavirus DNA (HPV DNA) and p16 and p53 protein expressions
were investigated for their role in transforming dysplasia into squamous cell carcinoma of …
were investigated for their role in transforming dysplasia into squamous cell carcinoma of …
Chromosomal signatures of a subset of high-grade premalignant cervical lesions closely resemble invasive carcinomas
SM Wilting, RDM Steenbergen, M Tijssen… - Cancer research, 2009 - AACR
Cervical cancer develops from precancerous high-grade cervical intraepithelial neoplasia
(CIN) harboring a transforming infection with high-risk human papillomavirus, which is …
(CIN) harboring a transforming infection with high-risk human papillomavirus, which is …
Evaluation of p16, human papillomavirus capsid protein L1 and Ki-67 in cervical intraepithelial lesions: Potential utility in diagnosis and prognosis
HAS Alshenawy - Pathology-Research and Practice, 2014 - Elsevier
Cervical dysplasia, a potentially precancerous lesion, has increased in young women.
Detection of cervical dysplasia is important for reducing morbidity and mortality in cervical …
Detection of cervical dysplasia is important for reducing morbidity and mortality in cervical …
A comparative analysis of clinical and molecular factors with the stage of cervical cancer in a Brazilian cohort
SM Amaro-Filho, JE Golub, GJ Nuovo, CB Cunha… - PLoS …, 2013 - journals.plos.org
Cell cycle protein expression plays an important role in the pathophysiology of cervical
cancer. However, few studies have attempted to correlate the use of these biomarkers with …
cancer. However, few studies have attempted to correlate the use of these biomarkers with …
Prognostic significance of p16 expression in advanced cervical cancer treated with definitive radiotherapy
JK Schwarz, JS Lewis Jr, J Pfeifer, P Huettner… - International Journal of …, 2012 - Elsevier
PURPOSE: The purpose of this study was to evaluate the prognostic significance of p16
immunohistochemistry (IHC) in patients with advanced cervical cancer treated with radiation …
immunohistochemistry (IHC) in patients with advanced cervical cancer treated with radiation …