The neural crest and craniofacial placodes are two distinct progenitor populations that arise
at the border of the vertebrate neural plate. This border region develops through a series of …

The mammalian brain develops through a complex interplay of spatial cues generated by
diffusible morphogens, cell–cell interactions and intrinsic genetic programs that result in …

Specialized sensory organs in the vertebrate head originate from thickenings in the
embryonic ectoderm called cranial sensory placodes. These placodes, as well as the neural …

Long non-coding RNAs (lncRNAs) play important roles in epigenetic regulation of skeletal
muscle development. In our previous RNA-seq study (accession number GSE58755), we …

In the vertebrate head, crucial parts of the sense organs and sensory ganglia develop from
special regions, the cranial placodes. Despite their cellular and functional diversity, they …

Nephron endowment is determined by the self-renewal and induction of a nephron
progenitor pool established at the onset of kidney development. In the mouse, the related …

Cranial sensory placodes derive from discrete patches of the head ectoderm and give rise to
numerous sensory structures. During gastrulation, a specialized “neural border zone” forms …

Lineage specification is governed by gene regulatory networks (GRNs) that integrate the
activity of signaling effectors and transcription factors (TFs) on enhancers. Sox17 is a key …

In the past two decades, many studies have shown that sine oculis homeobox 1 (Six1) is a
powerful regulator of organogenesis and disease, with important roles in tumorigenesis; …

DNA that controls gene expression (eg enhancers, promoters) has seemed almost never to
be conserved between distantly related animals, like vertebrates and arthropods. This is …