Melatonin is remarkably functionally diverse with actions as a free radical scavenger and
antioxidant, circadian rhythm regulator, anti‐inflammatory and immunoregulating molecule …

Melatonin has been speculated to be mainly synthesized by mitochondria. This speculation
is supported by the recent discovery that aralkylamine N-acetyltransferase/serotonin N …

While melatonin is known to have protective effects in mitochondria‐related diseases, aging,
and neurodegenerative disorders, there is poor understanding of the effects of melatonin …

The inflammatory response is induced by the overexpression of inflammatory cytokines,
mainly interleukin (IL)-1β, and is one of the main causes of intervertebral disc degeneration …

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease or Charcot
disease, is a fatal neurodegenerative disease that affects motor neurons (MNs) and leads to …

Melatonin, mostly released by the pineal gland, is a circadian rhythm-regulated and
multifunctional hormone. Great advances in melatonin research have been made, including …

Classically, mitochondria have largely been believed to influence the development of illness
by modulating cell metabolism and determining the rate of production of high-energy …

Nitric Oxide (NO) is a potent signaling molecule involved in the regulation of various cellular
mechanisms and pathways under normal and pathological conditions. NO production, its …

Melatonin is an endogenous hormone derived from tryptophan that is mainly released from
the pineal gland in the dark. Melatonin regulates many biological functions such as sleep …

Multiple sclerosis (MS) is a multifactorial disease of the central nervous system (CNS)
characterized by an inflammatory process and demyelination. The etiology of the disease is …