3D chromatin architecture and transcription regulation in cancer

S Deng, Y Feng, S Pauklin - Journal of hematology & oncology, 2022 - Springer
Chromatin has distinct three-dimensional (3D) architectures important in key biological
processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn …

Single-cell profiling of transcriptome and histone modifications with EpiDamID

FJ Rang, KL de Luca, SS de Vries, C Valdes-Quezada… - Molecular Cell, 2022 - cell.com
Recent advances in single-cell sequencing technologies have enabled simultaneous
measurement of multiple cellular modalities, but the combined detection of histone post …

Reorganization of lamina-associated domains in early mouse embryos is regulated by RNA polymerase II activity

M Pal, L Altamirano-Pacheco, T Schauer… - Genes & …, 2023 - genesdev.cshlp.org
Fertilization in mammals is accompanied by an intense period of chromatin remodeling and
major changes in nuclear organization. How the earliest events in embryogenesis, including …