Update on classical and atypical scrapie in sheep and goats

JJ Greenlee - Veterinary pathology, 2019 - journals.sagepub.com
Scrapie is a naturally occurring transmissible spongiform encephalopathy (TSE) or prion
disease of sheep and goats. Scrapie is a protein misfolding disease where the normal prion …

Differential accumulation of misfolded prion strains in natural hosts of prion diseases

ZJ Lambert, JJ Greenlee, ED Cassmann… - Viruses, 2021 - mdpi.com
Prion diseases, also known as transmissible spongiform encephalopathies (TSEs), are a
group of neurodegenerative protein misfolding diseases that invariably cause death. TSEs …

Potential scrapie-associated polymorphisms of the prion protein gene (PRNP) in Korean native black goats

SK Kim, YC Kim, SY Won, BH Jeong - Scientific Reports, 2019 - nature.com
Small ruminants, including sheep and goats are natural hosts of scrapie, and the
progression of scrapie pathogenesis is strongly influenced by polymorphisms in the prion …

Estimating relative CWD susceptibility and disease progression in farmed white-tailed deer with rare PRNP alleles

NJ Haley, K Merrett, A Buros Stein, D Simpson… - PLoS …, 2019 - journals.plos.org
Chronic wasting disease is a prion disease affecting both free-ranging and farmed cervids in
North America and Scandinavia. A range of cervid species have been found to be …

Scientific Opinion on the scrapie situation in the EU after 10 years of monitoring and control in sheep and goats

EFSA Panel on Biological Hazards (BIOHAZ) - EFSA Journal, 2014 - Wiley Online Library
To assess the effectiveness of the strategies implemented in the European Union (EU) to
control Classical scrapie (CS), epidemiological data have been compared in the context of …

Comparative Susceptibility of Sheep of Different Origins, Breeds and PRNP Genotypes to Challenge with Bovine Spongiform Encephalopathy and Scrapie

F Houston, W Goldmann, J Foster, L González… - PloS one, 2015 - journals.plos.org
Sheep are natural hosts of the prion disease, scrapie. They are also susceptible to
experimental challenge with various scrapie strains and with bovine spongiform …

Selective Breeding for Disease-Resistant PRNP Variants to Manage Chronic Wasting Disease in Farmed Whitetail Deer

N Haley, R Donner, K Merrett, M Miller, K Senior - Genes, 2021 - mdpi.com
Chronic wasting disease (CWD) is a fatal transmissible spongiform encephalopathy (TSE) of
cervids caused by a misfolded variant of the normal cellular prion protein, and it is closely …

Sheep with the homozygous lysine-171 prion protein genotype are resistant to classical scrapie after experimental oronasal inoculation

ED Cassmann, SJ Moore, JD Smith… - Veterinary …, 2019 - journals.sagepub.com
Scrapie is a fatal neurodegenerative disease of sheep resulting from the accumulation of a
misfolded form of the prion protein (PrPSc). Polymorphisms in the host prion protein gene …

Changes in retinal function and morphology are early clinical signs of disease in cattle with bovine spongiform encephalopathy

MH West Greenlee, JD Smith, EM Platt, JR Juarez… - PloS one, 2015 - journals.plos.org
Bovine spongiform encephalopathy (BSE) belongs to a group of fatal, transmissible protein
misfolding diseases known as transmissible spongiform encephalopathies (TSEs). All TSEs …

The prion protein family: a view from the placenta

S Makzhami, B Passet, S Halliez, J Castille… - Frontiers in cell and …, 2014 - frontiersin.org
Based on its developmental pattern of expression, early studies suggested the implication of
the mammalian Prion protein PrP, a glycosylphosphatidylinositol-anchored ubiquitously …