During the past decade, research has revealed that the vast community of micro-organisms
that inhabit the gut—known as the gut microbiota—is intricately linked to human health and …

Ulcerative colitis and Crohn's disease are chronic inflammatory intestinal diseases with
perplexing heterogeneity in disease manifestation and response to treatment. While the …

In addition to maintaining immune tolerance, FOXP3+ regulatory T (Treg) cells perform
specialized functions in tissue homeostasis and remodelling,. However, the characteristics …

Interactions between the nervous and immune systems enable the gut to respond to the
variety of dietary products that it absorbs, the broad spectrum of pathogens that it …

Abstract Serotonin (5-HT), a well-known neurotransmitter in the brain, also plays an
important role in peripheral tissues, including the immune system. There is a growing body …

Metabolism is one of the strongest drivers of interkingdom interactions—including those
between microorganisms and their multicellular hosts. Traditionally thought to fuel energy …

The microbiota-gut-brain-axis (MGBA) is a bidirectional communication network between gut
microbes and their host. Many environmental and host-related factors affect the gut …

Platelet-derived peripheral serotonin has pleiotropic effects on coagulation, metabolism,
tissue regeneration, and cancer growth; however, the effect of serotonin on the tumor …

Abstract Serotonin or 5‐hydroxytryptamine (5‐HT) is a neurotransmitter and hormone that
contributes to the regulation of various physiological functions by its actions in the central …

The current understanding of inflammatory bowel disease (IBD) pathogenesis implicates a
complex interaction between host genetics, host immunity, microbiome, and environmental …