Environmental variations induced by industrialization and climate change partially explain
the increase in prevalence and severity of allergic disease. One possible mechanism is the …

The Th2 immune response, culminating in eosinophilia and IgE production, is not only
characteristic of allergy but also of infection by parasitic worms (helminths). Anti-parasite IgE …

Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967,
our knowledge about the immunological mechanisms of IgE‐mediated allergies has …

The availability of allergen molecules ('components') from several protein families has
advanced our understanding of immunoglobulin E (IgE)‐mediated responses and enabled …

Background While it is suggested that the prevalence of asthma in developed countries may
have stabilized, this is not clear in currently developing countries. Current available …

Allergic diseases are distributed worldwide and their risk factors and triggers vary according
to geographical and socioeconomic conditions. Allergies are frequent in the Tropics but …

House dust mite (HDM) allergy belongs to the most important allergies and affects
approximately 65–130 million people worldwide. Additionally, untreated HDM allergy may …

A large number of allergens have been discovered but we know little about their potential to
induce inflammation (allergenic activity) and symptoms. Nowadays, the clinical importance …

Microbiome and the immune system are constantly shaping each other, in a mutual aim to
thrive, defining the unstable equilibrium of the healthy individual. Microbiome is growingly …

Geography of house dust mite allergens Page 1 211 Review article Geography of house dust
mite allergens Wayne R Thomas 1 Summary Objective: To consider how the different …