Glucocorticoids have pleiotropic effects that are used to treat diverse diseases such as
asthma, rheumatoid arthritis, systemic lupus erythematosus and acute kidney transplant …

Pharmacodynamics is the study of the time course of pharmacological effects of drugs. The
field of pharmacodynamic modeling has made many advances, due in part to the relatively …

Drugs that bind with high affinity and to a significant extent (relative to dose) to a
pharmacologic target such as an enzyme, receptor, or transporter may exhibit nonlinear …

Population pharmacodynamic (PD) models describe the time course of drug effects, relating
exposure to response, and providing a more robust understanding of drug action than single …

With the advancement of technology, drug delivery systems and molecules with more
complex architecture are developed. As a result, the drug absorption and disposition …

Updated with new chapters and topics, this book provides a comprehensive description of
all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also …

Nonlinear pharmacokinetics and pharmacodynamics may result from several capacity-
limited processes and often represent complicating factors in characterizing the …

Mechanism-based pharmacokinetic and pharmacodynamics (PKPD) and disease system
(DS) models have been introduced in drug discovery and development research, to predict …

Abstract Purpose: Targeting Bcl-2 family members upregulated in multiple cancers has
emerged as an important area of cancer therapeutics. While venetoclax, a Bcl-2–selective …

Purpose: Selective inhibition of cyclin-dependent kinases 4 and 6 (CDK4/6) represents a
promising therapeutic strategy. However, despite documented evidence of clinical activity …