The development and clinical application of innovative optical ophthalmic imaging techniques

P Alexopoulos, C Madu, G Wollstein… - Frontiers in …, 2022 - frontiersin.org
The field of ophthalmic imaging has grown substantially over the last years. Massive
improvements in image processing and computer hardware have allowed the emergence of …

OCT Prognostic Biomarkers for Progression to Late Age-related Macular Degeneration: A Systematic Review and Meta-analysis

M Trinh, R Cheung, A Duong, L Nivison-Smith… - Ophthalmology Retina, 2023 - Elsevier
Topic To evaluate which OCT prognostic biomarkers best predict the risk of progression from
early/intermediate to late age-related macular degeneration (AMD). Clinical Relevance …

Two-step hierarchical neural network for classification of dry age-related macular degeneration using optical coherence tomography images

M Hu, B Wu, D Lu, J Xie, Y Chen, Z Yang… - Frontiers in Medicine, 2023 - frontiersin.org
Purpose The aim of this study is to apply deep learning techniques for the development and
validation of a system that categorizes various phases of dry age-related macular …

Automated Identification and Segmentation of Ellipsoid Zone At-Risk Using Deep Learning on SD-OCT for Predicting Progression in Dry AMD

G Kalra, H Cetin, J Whitney, S Yordi, Y Cakir… - Diagnostics, 2023 - mdpi.com
Background: The development and testing of a deep learning (DL)-based approach for
detection and measurement of regions of Ellipsoid Zone (EZ) At-Risk to study progression in …

Impact of baseline quantitative OCT features on response to risuteganib for the treatment of dry age-related macular degeneration: the importance of outer retinal …

JR Abraham, GJ Jaffe, PK Kaiser, SJ Chiu, J Loo… - Ophthalmology …, 2022 - Elsevier
Objective The purpose of the study was to perform a post hoc analysis to explore the effect of
baseline anatomic characteristics identified on OCT on best-corrected visual acuity (BCVA) …

Combination of optical coherence tomography-derived shape and texture features are associated with development of sub-foveal geographic atrophy in dry AMD

SS Kar, H Cetin, J Abraham, SK Srivastava… - Scientific Reports, 2024 - nature.com
Geographic atrophy (GA) is an advanced form of dry age-related macular degeneration
(AMD) that leads to progressive and irreversible vision loss. Identifying patients with greatest …

Imaging geographic atrophy: integrating structure and function to better understand the effects of new treatments

S Vujosevic, A Loewenstein, L O'Toole… - British Journal of …, 2024 - bjo.bmj.com
Geographic atrophy (GA) is an advanced and irreversible form of age-related macular
degeneration (AMD). Chronic low grade inflammation is thought to act as an initiator of this …

C5 inhibitor avacincaptad pegol treatment for geographic atrophy: A comprehensive review

CJ Danzig, AM Khanani, A Loewenstein - Immunotherapy, 2024 - Taylor & Francis
Geographic atrophy (GA) remains a leading cause of central vision loss with no known cure.
Until recently, there were no approved treatments for GA, often resulting in poor quality of life …

Implementing predictive models in artificial intelligence through OCT biomarkers for age-related macular degeneration

S Fragiotta, F Grassi, S Abdolrahimzadeh - Photonics, 2023 - mdpi.com
Artificial intelligence (AI) represents a growing and promising branch of computer science
that is expanding the horizon of prediction, screening, and disease monitoring. The use of …

[HTML][HTML] Correlation Between Blue Fundus Autofluorescence and SD-OCT Measurements of Geographic Atrophy in Dry Age-Related Macular Degeneration

JP Ehlers, C McConville, S Yordi, H Cetin… - American Journal of …, 2024 - Elsevier
Purpose To compare fundus autofluorescence (FAF) and spectral domain-optical coherence
tomography (OCT) measurements of geographic atrophy (GA) area and to analyze lesion …