CREB binding protein (CBP) and p300 were both identified initially in protein interaction
assays–the former through its association with the transcription factor CREB (Chrivia et al …

ETS-domain transcription-factor networks represent a model for how combinatorial gene
expression is achieved. These transcription factors interact with a multitude of co-regulatory …

Protein folding is inherently a heterogeneous process because of the very large number of
microscopic pathways that connect the myriad unfolded conformations to the unique …

The Ets1 proto-oncoprotein is a member of the Ets family of transcription factors that share a
unique DNA binding domain, the Ets domain. The DNA binding activity of Ets1 is controlled …

Ets1 belongs to the large family of the ETS domain family of transcription factors and is
involved in cancer progression. In most carcinomas, Ets1 expression is linked to poor …

Seven major cell–cell signaling pathways—Wnt, TGF-ß, Hedgehog (Hh), receptor tyrosine
kinase (RTK), nuclear receptor, Jak/STAT, and Notch—control the vast majority of cell fate …

The transcription factor YY1 is a complex protein that is involved in repressing and activating
a diverse number of promoters. Numerous studies have attempted to understand how this …

Recruitment of p300/CBP by the hypoxia-inducible factor, HIF-1, is essential for the
transcriptional response to hypoxia and requires an interaction between the p300/CBP CH1 …

Ets is a family of transcription factors present in species ranging from sponges to human. All
family members contain an approximately 85 amino acid DNA binding domain, designated …

Genes encoding the Phe-Gly (FG) repeat-containing nucleoporins NUP98 and
CAN/NUP214 are at the breakpoints of several chromosomal translocations associated with …