Pathogenesis of pneumonia and acute lung injury
ME Long, RK Mallampalli, JC Horowitz - Clinical Science, 2022 - portlandpress.com
Pneumonia and its sequelae, acute lung injury, present unique challenges for pulmonary
and critical care healthcare professionals, and these challenges have recently garnered …
and critical care healthcare professionals, and these challenges have recently garnered …
MAP kinase kinase 1 (MEK1) within extracellular vesicles inhibits tumour growth by promoting anti‐tumour immunity
SC Searles, WS Chen, JD Yee, P Lee… - Journal of …, 2024 - Wiley Online Library
Extracellular vesicles (EVs) mediate intercellular communication in many physiologic
processes and can modulate immune responses in individuals with cancer. Most studies of …
processes and can modulate immune responses in individuals with cancer. Most studies of …
[HTML][HTML] MEK1 regulates pulmonary macrophage inflammatory responses and resolution of acute lung injury
ME Long, KQ Gong, WE Eddy, JS Volk, ED Morrell… - JCI insight, 2019 - ncbi.nlm.nih.gov
Abstract The MEK1/2–ERK1/2 pathway has been implicated in regulating the inflammatory
response to lung injury and infection, and pharmacologic MEK1/2 inhibitor compounds are …
response to lung injury and infection, and pharmacologic MEK1/2 inhibitor compounds are …
Dual role for a MEK inhibitor as a modulator of inflammation and host defense mechanisms with potential therapeutic application in COPD
Background Unlike p38 mitogen-activated protein Kinases (MAPK) that has been
extensively studied in the context of lung-associated pathologies in COPD, the role of the …
extensively studied in the context of lung-associated pathologies in COPD, the role of the …
MEK1/2 inhibition decreases pro-inflammatory responses in macrophages from people with cystic fibrosis and mitigates severity of illness in experimental murine …
Chronic pulmonary bacterial infections and associated inflammation remain a cause of
morbidity and mortality in people with cystic fibrosis (PwCF) despite new modulator …
morbidity and mortality in people with cystic fibrosis (PwCF) despite new modulator …
Matrix metalloproteinase 28 is regulated by TRIF-and type I IFN-dependent signaling in macrophages
ME Long, KQ Gong, JS Volk, WE Eddy… - Innate …, 2018 - journals.sagepub.com
Matrix metalloproteinases (MMPs) are transcriptionally regulated proteases that have
multiple roles in modifying the extracellular matrix (ECM) and inflammatory response. Our …
multiple roles in modifying the extracellular matrix (ECM) and inflammatory response. Our …
MEK1/2 inhibition decreases pro-inflammatory responses in macrophages from people with cystic fibrosis and mitigates severity of illness in experimental murine …
Chronic pulmonary bacterial infections and associated inflammation remain a cause of
morbidity and mortality in people with cystic fibrosis (PwCF) despite new modulator …
morbidity and mortality in people with cystic fibrosis (PwCF) despite new modulator …
MAP2K2 delays recovery in murine models of acute lung injury and associates with acute respiratory distress syndrome outcome
KQ Gong, C Mikacenic, ME Long… - American journal of …, 2022 - atsjournals.org
Acute respiratory distress syndrome (ARDS) remains a significant problem in need of new
pharmaceutical approaches to improve its resolution. Studies comparing gene expression …
pharmaceutical approaches to improve its resolution. Studies comparing gene expression …