Stress during critical periods of development and risk for schizophrenia

FV Gomes, X Zhu, AA Grace - Schizophrenia research, 2019 - Elsevier
Schizophrenia is a neurodevelopmental disorder with genetic predisposition, and stress has
long been linked to its etiology. While stress affects all stages of the illness, increasing …

[HTML][HTML] Developments in biological mechanisms and treatments for negative symptoms and cognitive dysfunction of schizophrenia

Q Wu, X Wang, Y Wang, YJ Long, JP Zhao… - Neuroscience Bulletin, 2021 - Springer
The causal mechanisms and treatment for the negative symptoms and cognitive dysfunction
in schizophrenia are the main issues attracting the attention of psychiatrists over the last …

[HTML][HTML] Directly and indirectly targeting the glycine modulatory site to modulate NMDA receptor function to address unmet medical needs of patients with …

JC Pei, DZ Luo, SS Gau, CY Chang, WS Lai - Frontiers in Psychiatry, 2021 - frontiersin.org
Schizophrenia is a severe mental illness that affects~ 1% of the world's population. It is
clinically characterized by positive, negative, and cognitive symptoms. Currently available …

Predictive validity of conversion from the clinical high risk syndrome to frank psychosis

LAY Sykes, M Ferrara, J Addington, CE Bearden… - Schizophrenia …, 2020 - Elsevier
Although the clinical high risk for psychosis (CHR) paradigm has become well-established
over the past two decades, one key component has received surprisingly little investigative …

[HTML][HTML] MDMA for the Treatment of Negative Symptoms in Schizophrenia

MD Arnovitz, AJ Spitzberg, AJ Davani… - Journal of Clinical …, 2022 - mdpi.com
The profound economic burden of schizophrenia is due, in part, to the negative symptoms of
the disease, which can severely limit daily functioning. There is much debate in the field …

[HTML][HTML] Genetic Variations of DAOA (rs947267 and rs3918342) and COMT Genes (rs165599 and rs4680) in Schizophrenia and Bipolar I Disorder

L Ahmadi, SRK Nezhad, P Behbahani… - Basic and Clinical …, 2018 - ncbi.nlm.nih.gov
Methods: Blood samples (n= 100 for schizophrenia, n= 100 for bipolar I disorder and n= 127
for case control) were collected from individuals unrelated in the southwest of Iran. The …

Association of negative symptoms with cognitive impairment in Chinese Han patients with chronic schizophrenia

R Zhu, D Wang, G Wei, J Wang, H Zhou… - … Journal of Psychiatry …, 2021 - Taylor & Francis
Objective Cognitive impairment is an essential feature of schizophrenia; however, the
relationship between clinical psychiatric symptoms with cognitive impairment is still unclear …

The motivation and pleasure deficits but not expressivity affects social functioning through cognitive function in male patients with schizophrenia: A structural equation …

R Cai, C Huang, L Ni, Z Liu, S Zhang, Y Qiu, J Hu… - Asian Journal of …, 2023 - Elsevier
Objective This study aims to compare cognitive function and social functioning in male
schizophrenia patients with deficit syndrome (DS) and non-DS, and to explore the …

Gene Polymorphisms and Expression of NRG1, DAOA, and DISC1 Genes in a Chinese Han Population with an Ultra-High Risk for Psychosis

XY He, ZH Huang, F Wang, ZL Chen… - Neuropsychiatric …, 2023 - Taylor & Francis
Purpose Although there is previous evidence supporting that ultra-high risk (UHR) for
psychosis transformation is associated with NRG1, DAOA, and DISC1 genes, there have …

[HTML][HTML] A dopamine receptor D2 genetic polymorphism associated with transition to mental disorders in a cohort of individuals with at-risk mental state for psychosis

JH Marques, LL Talib, L Hortêncio… - Brazilian Journal of …, 2023 - SciELO Brasil
Objectives: To test the association of 45 single nucleotide polymorphisms (SNPs) with
transition to psychiatric disorders in a cohort of individuals at ultrahigh risk (UHR) mental …