Osteoarthritis is a degenerative joint disease characterized by pain and disability. It involves
all ages and 70% of people aged> 65 have some degree of osteoarthritis. Natural cartilage …

Cartilage defects in the knee are often seen in young and active patients. There is a need for
effective joint preserving treatments in patients suffering from cartilage defects, as untreated …

Cartilage is a hydrated soft tissue whose solid matrix consists of negatively charged
proteoglycans enmeshed within a fibrillar collagen network. Though many aspects of …

There is a need for materials that are well suited for cartilage tissue engineering. Hydrogels
have emerged as promising biomaterials for cartilage repair, since, like cartilage, they have …

The negatively charged proteoglycans (PG) provide compressive resistance to articular
cartilage by means of their fixed charge density (FCD) and high osmotic pressure (π PG) …

Understanding the mechanics behind knee joint injuries and providing appropriate
treatment is crucial for improving physical function, quality of life, and employability. In this …

Cartilage is a multi-phase material composed of fluid and electrolytes (68–85% by wet
weight), proteoglycans (5–10% by wet weight), chondrocytes, collagen fibres and other …

OBJECTIVE: The composition of articular cartilage changes with progression of
osteoarthritis. Since compositional changes are associated with changes in the mechanical …

While it is well established that the composition and organisation of articular cartilage
dramatically change during skeletal maturation, relatively little is known about how this …

Objective Proteoglycan (PG) loss and surface roughening, early signs of osteoarthritis (OA),
are likely preceded by softening of the ground substance and the collagen network. Insight …