We review recent data that increase our understanding of the ternary complex of the T cell
receptor (TCR), antigenic peptides, and molecules of the major histocompatibility complex …

Despite accumulating evidence that regulatory T cells play a crucial role in preventing
autoimmunity, the processes underlying their generation during immune repertoire formation …

Soon after methicillin was introduced into clinical practice in the early 1960s, resistant
strains of Staphylococcus aureus (MRSA) appeared, bearing a newly acquired resistance …

THE T-cell receptor is necessary and sufficient for recognition of peptides presented by
major histocompatibility complex molecules1, 2. Other adhesion molecules, like CD4 or …

Recent studies mdtcate that the T-cell receptor (TCR) repertoire selected by certam
antigenic peptide-MHC combinations can be extremely &verse. This is in contrast to earher …

Synthetic peptides corresponding to microbial epitopes stimulate T cell immunity but their
immunogenicity is poor and their half-lives are short. A viral epitope inserted into the …

Recovery from influenza virus infection is dependent on T cell functions which can be
provided either by CD8 or CD4 T cells. To identify the functions involved in recovery …

Neonates and infants display an intrinsic disability to mount protective immune responses to
influenza viruses or conventional influenza vaccines. We investigated the ability of naked …

Interaction between a T cell receptor (TCR) and various ligands, ie, anti-TCR antibodies,
superantigens, peptides, or altered peptide ligands in the context of major histocompatibility …

We studied the effect of lung-specific IL-4 expression on the T cell response during primary
and secondary heterologous infection with influenza virus by using transgenic mice that …