Following periods of haematopoietic cell stress, such as after chemotherapy, radiotherapy,
infection and transplantation, patient outcomes are linked to the degree of immune …

The timely reconstitution and regain of function of a donor-derived immune system is of
utmost importance for the recovery and long-term survival of patients after allogeneic …

BACKGROUND Understanding outcomes and immunologic characteristics of cellular
therapy recipients with SARS-CoV-2 is critical to performing these potentially life-saving …

We developed a computational method to infer the complementarity-determining region 3
(CDR3) sequences of tumor-infiltrating T cells in 9,142 RNA-seq samples across 29 cancer …

The peculiarity of T cell is their ability to recognize an infinite range of self and foreign
antigens. This ability is achieved during thymic development through a complex molecular …

T cells are the central drivers of many inflammatory diseases, but the repertoire of tissue-
resident T cells at sites of pathology in human organs remains poorly understood. We …

Autologous hematopoietic stem cell transplantation (HSCT) is commonly employed for
hematologic and non-hematologic malignancies. In clinical trials, HSCT has been evaluated …

Background Ipilimumab improves overall survival in a subset of patients with metastatic
melanoma. Peripheral blood T cell receptor (TCR) repertoire diversity has been associated …

T-cell antigen receptor (TCR) variability enables the cellular immune system to discriminate
between self and non-self. High-throughput TCR sequencing (TCR-seq) involves the use of …

Successful immune reconstitution (IR) is associated with improved outcomes following
pediatric cord blood transplantation (CBT). Usage and timing of anti–thymocyte globulin …