The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …

Abstract Introduction The Fibroblast Growth Factor Receptor (FGFR) family consists of
Tyrosine Kinase Receptors (TKR) involved in several biological functions. Recently …

Increasing evidence indicates that success of targeted therapies in the treatment of cancer is
context-dependent and is influenced by a complex crosstalk between signaling pathways …

Introduction: Deregulation of the fibroblast growth factor (FGF)/FGF receptor (FGFR) network
occurs frequently in tumors due to gene amplification, activating mutations, and oncogenic …

Fibroblast growth factor receptor 1 (FGFR1) is overexpressed in multiple types of solid
tumors, including head and neck squamous cell carcinoma (HNSCC). Being associated with …

Purpose: FGFR1 copy-number gain (CNG) occurs in head and neck squamous cell cancers
(HNSCC) and is used for patient selection in FGFR-specific inhibitor clinical trials. This study …

Cancer stemness is associated with high malignancy and low differentiation, as well as
therapeutic resistance of tumors including pancreatic ductal adenocarcinoma (PDAC) …

Recently, fibroblast growth factors are identified to play a vital role in the development and
progression of human pancreatic cancer. FGF pathway is critical involved in numerous …

Pancreatic adenocarcinoma (PDAC) is projected to become the second leading cause of
cancer deaths by 2030, and its five-year survival is 12%(Rahib et al., 2014; Siegel, Miller …

Background Fibroblast growth factor receptor (FGFR) gene amplification has been reported
in different types of cancer. We performed an up-to-date meta-analysis to further …