Long known as terminal degradation stations, lysosomes have emerged as sophisticated
signalling centres that govern cell growth, division and differentiation. Lysosomes interface …

Autophagy is a lysosomal degradative process used to recycle obsolete cellular constituents
and eliminate damaged organelles and protein aggregates. These substrates reach …

Background Glioblastoma multiforme (GBM) is the most common cancer of the central
nervous system, while Parkinson's disease (PD) is a degenerative neurological condition …

Mammalian cells remove misfolded proteins using various proteolytic systems, including the
ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and …

TOR (target of rapamycin) and its mammalian ortholog mTOR have been discovered in an
effort to understand the mechanisms of action of the immunosuppressant drug rapamycin …

The mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in
regulating cell growth, proliferation, and life span. mTOR signaling is a central regulator of …

A significant number of the anti-inflammatory drugs currently in use are becoming obsolete.
These are exceptionally hazardous for long-term use because of their possible unfavourable …

Since the discovery of the phosphorylation of the 40S ribosomal protein S6 (rpS6) about four
decades ago, much effort has been made to uncover the molecular mechanisms underlying …

Parkinson's disease (PD) is a progressive neurodegenerative disorder resulting from the
death of dopamine neurons in the substantia nigra pars compacta. Our understanding of PD …

Neurodegenerative diseases, such as Alzheimer's disease Parkinson's disease,
Huntington's disease, and amyotrophic lateral sclerosis, share a common cellular and …