Saccharomyces cerevisiae, the budding yeast, is the most thoroughly studied eukaryote at
the cellular, molecular, and genetic levels. Yet, until recently, we knew very little about its …

Regulation of cell growth in response to nutrients is crucial for the survival of all organisms.
In yeast, cell growth and division require two signaling pathways, TORC1 and PKA …

The CRISPR/Cas9 system has been applied to efficient genome editing in many eukaryotic
cells. However, the bases that can be edited by this system have been limited to those within …

Modern experimental technology enables the identification of the sensory proteins that
interact with the cells' environment or various pathogens. Expression and knockdown …

Developing more robust and productive industrial yeast is crucial for high-efficiency
biomanufacturing. However, the challenges posed by the long time required and the low …

Proline is a predominant amino acid in grape must, but it is poorly utilized by the yeast
Saccharomyces cerevisiae in wine-making processes. This sometimes leads to a nitrogen …

Modification of cell cycle in entomopathogenic fungi is likely crucial for host infection and
environmental adaptation. Here we show that W ee1 and Cdc 25 can balance cell cycle …

Hsf1p, the heat-shock transcription factor from Saccharomyces cerevisiae, has a low level of
constitutive transcriptional activity and is kept in this state through negative regulation. In an …

Ras guanine nucleotide exchange factors (RasGEFs) can trigger Ras GTPase activities and
play important roles in controlling various cellular processes in eukaryotes. Recently, it has …

Ras GTPases act as molecular switches to control various cellular processes by coupling
integrated signals in eukaryotes. Activities of Ras GTPases are triggered by Ras GTPase …