Recent developments on the synthesis and applications of betulin and betulinic acid derivatives as therapeutic agents
SC Jonnalagadda, P Suman, DC Morgan… - Studies in Natural …, 2017 - Elsevier
Triterpenes are widely found amongst various natural sources and are derived from
squalene or related 30-carbon acyclic congeners. Medicinal plants are an excellent source …
squalene or related 30-carbon acyclic congeners. Medicinal plants are an excellent source …
Synthesis, structure and cytotoxic activity of new acetylenic derivatives of betulin
S Boryczka, E Bębenek, J Wietrzyk, K Kempińska… - Molecules, 2013 - mdpi.com
A new series of betulin derivatives containing one or two pharmacophores bearing an
acetylenic and carbonyl function at the C-3 and/or C-28 positions has been synthesized and …
acetylenic and carbonyl function at the C-3 and/or C-28 positions has been synthesized and …
Transformations of pentacyclic triterpenoids as a route to the future medicines
LA Baltina, NG Komissarova - Studies in Natural Products Chemistry, 2023 - Elsevier
Plant-derived natural products (plant secondary metabolites) are an inexhaustible source for
the new bioactive substances due to the large structural diversity and a broad spectrum of …
the new bioactive substances due to the large structural diversity and a broad spectrum of …
Cytotoxic betulin-derived hydroxypropargylamines trigger apoptosis
Several novel betulin derivatives were prepared and evaluated for their antitumor activity.
Among others, 3-O-acetylbetulinic aldehyde served as an ideal starting material for the …
Among others, 3-O-acetylbetulinic aldehyde served as an ideal starting material for the …
Synthesis of Antitumor‐Active Betulinic Acid‐Derived Hydroxypropargylamines by Copper‐Catalyzend Mannich Reactions
Several novel betulin derivates were prepared using Mannich reactions as a key step.
Starting from 3‐ethynyl‐3‐hydroxy‐lup‐20 (29)‐ene derivatives, copper‐catalyzed Mannich …
Starting from 3‐ethynyl‐3‐hydroxy‐lup‐20 (29)‐ene derivatives, copper‐catalyzed Mannich …
[HTML][HTML] One-Stage Pathway from Hollongdione to C17-Alkyne and Vinyl Chloride Following Mannich Bases and Carboxylic Acid
Z Galimova, I Smirnova, A Lobov… - International Journal of …, 2024 - mdpi.com
Hollongdione is the first recorded example of the occurrence of a dammarane hexanor-
triterpene in nature possessing antiviral and cytotoxic activity. Its simple one-stage …
triterpene in nature possessing antiviral and cytotoxic activity. Its simple one-stage …
Homo‐and cross coupling of C‐2 propargyl substituted triterpenoic acids: Synthesis of novel symmetrical and unsymmetrical triterpene 1, 3‐diynes
RR Gubaidullin, RR Khalitova, DA Nedopekina… - …, 2018 - Wiley Online Library
A synthesis of the first representatives of symmetrical and unsymmetrical triterpene 1, 3‐
diynes in which one or two triterpene cores are linked by a diyne spacer at the C‐2 position …
diynes in which one or two triterpene cores are linked by a diyne spacer at the C‐2 position …
Advances in chemistry and pharmacology of triterpenoid synthetic dimers
B Bednarczyk-Cwynar, A Günther - Current Medicinal …, 2017 - ingentaconnect.com
This review focuses on advances in chemistry and pharmacology of synthetic triterpenoid
dimers, obtained from natural compounds. Synthetic triterpenoid dimers are divided into …
dimers, obtained from natural compounds. Synthetic triterpenoid dimers are divided into …
[PDF][PDF] Triterpenoidy lupanowe w syntezie zwiazków biologicznie czynnych
K Kuczyńska - 2019 - rcin.org.pl
Betulina 1 jest jedną z pierwszych substancji wyizolowanych z roślin. W 1877 roku wydzielił
ją przypadkowo z kory brzozy brodawkowatej Betula verrucosa Ehrh. rosyjski naukowiec TE …
ją przypadkowo z kory brzozy brodawkowatej Betula verrucosa Ehrh. rosyjski naukowiec TE …
[引用][C] Betulin-betulinic acid natural product based analogs as anti-cancer agents
SC Jonnalagadda, MA Corsello… - Anti-Cancer Agents in …, 2013 - ingentaconnect.com
Betulin-Betulinic Acid Natural Product Based Analogs as Anti-Cancer Agents Page 1 Send
Orders for Reprints to reprints@benthamscience.net Anti-Cancer Agents in Medicinal …
Orders for Reprints to reprints@benthamscience.net Anti-Cancer Agents in Medicinal …