The biological applications of DNA nanomaterials: current challenges and future directions

W Ma, Y Zhan, Y Zhang, C Mao, X Xie… - Signal transduction and …, 2021 - nature.com
DNA, a genetic material, has been employed in different scientific directions for various
biological applications as driven by DNA nanotechnology in the past decades, including …

DNA functional materials assembled from branched DNA: design, synthesis, and applications

Y Dong, C Yao, Y Zhu, L Yang, D Luo… - Chemical Reviews, 2020 - ACS Publications
DNA is traditionally known as a central genetic biomolecule in living systems. From an
alternative perspective, DNA is a versatile molecular building-block for the construction of …

DNA nanotechnology-enabled drug delivery systems

Q Hu, H Li, L Wang, H Gu, C Fan - Chemical reviews, 2018 - ACS Publications
Over the past decade, we have seen rapid advances in applying nanotechnology in
biomedical areas including bioimaging, biodetection, and drug delivery. As an emerging …

Supramolecular chemotherapy based on host–guest molecular recognition: a novel strategy in the battle against cancer with a bright future

J Zhou, G Yu, F Huang - Chemical Society Reviews, 2017 - pubs.rsc.org
Chemotherapy is currently one of the most effective ways to treat cancer. However,
traditional chemotherapy faces several obstacles to clinical trials, such as poor …

Hybridization chain reaction: a versatile molecular tool for biosensing, bioimaging, and biomedicine

S Bi, S Yue, S Zhang - Chemical Society Reviews, 2017 - pubs.rsc.org
Developing powerful, simple and low-cost DNA amplification techniques is of great
significance to bioanalysis and biomedical research. Thus far, many signal amplification …

Nanoscale self-assembly for therapeutic delivery

S Yadav, AK Sharma, P Kumar - Frontiers in Bioengineering and …, 2020 - frontiersin.org
Self-assembly is the process of association of individual units of a material into highly
arranged/ordered structures/patterns. It imparts unique properties to both inorganic and …

Aptamer-based targeted delivery of functional nucleic acids

S Xie, W Sun, T Fu, X Liu, P Chen, L Qiu… - Journal of the …, 2023 - ACS Publications
Functional nucleic acid (NA)-based drugs have a broad range of applications since they
allow the alteration and control of gene/protein expression patterns in cells. In principle …

Self-assembling nucleic acid nanostructures functionalized with aptamers

A Krissanaprasit, CM Key, S Pontula… - Chemical …, 2021 - ACS Publications
Researchers have worked for many decades to master the rules of biomolecular design that
would allow artificial biopolymer complexes to self-assemble and function similarly to the …

Rationally engineered nucleic acid architectures for biosensing applications

M Xiao, W Lai, T Man, B Chang, L Li… - Chemical …, 2019 - ACS Publications
Development of biosensing platforms plays a key role in research settings for identification
of biomarkers and in clinical applications for diagnostics. Biosensors based on nucleic acids …

Functional nucleic acid-based hydrogels for bioanalytical and biomedical applications

J Li, L Mo, CH Lu, T Fu, HH Yang, W Tan - Chemical Society Reviews, 2016 - pubs.rsc.org
Hydrogels are crosslinked hydrophilic polymers that can absorb a large amount of water. By
their hydrophilic, biocompatible and highly tunable nature, hydrogels can be tailored for …