[HTML][HTML] Current advancements in spinal cord Injury Research—glial scar formation and neural regeneration

T Clifford, Z Finkel, B Rodriguez, A Joseph, L Cai - Cells, 2023 - mdpi.com
Spinal cord injury (SCI) is a complex tissue injury resulting in permanent and degenerating
damage to the central nervous system (CNS). Detrimental cellular processes occur after SCI …

[HTML][HTML] Recent advances in endogenous neural stem/progenitor cell manipulation for spinal cord injury repair

J Li, W Luo, C Xiao, J Zhao, C Xiang, W Liu, R Gu - Theranostics, 2023 - ncbi.nlm.nih.gov
Traumatic spinal cord injury (SCI) can cause severe neurological impairments. Clinically
available treatments are quite limited, with unsatisfactory remediation effects. Residing …

Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances

SM Hosseini, B Borys, S Karimi-Abdolrezaee - Brain, 2024 - academic.oup.com
Traumatic spinal cord injury (SCI) is a leading cause of lifelong disabilities. Permanent
sensory, motor and autonomic impairments after SCI are substantially attributed to …

[HTML][HTML] Diversity of adult neural stem and progenitor cells in physiology and disease

Z Finkel, F Esteban, B Rodriguez, T Fu, X Ai, L Cai - Cells, 2021 - mdpi.com
Adult neural stem and progenitor cells (NSPCs) contribute to learning, memory,
maintenance of homeostasis, energy metabolism and many other essential processes. They …

In vivo cell fate reprogramming for spinal cord repair

W Tai, CL Zhang - Current opinion in genetics & development, 2023 - Elsevier
Spinal cord injury (SCI) can lead to the loss of motor, sensory, or autonomic function due to
neuronal death. Unfortunately, the adult mammalian spinal cord has limited intrinsic …

[HTML][HTML] Endogenous neural stem cells characterization using omics approaches: Current knowledge in health and disease

V Murtaj, E Butti, G Martino… - Frontiers in Cellular …, 2023 - frontiersin.org
Neural stem cells (NSCs), an invaluable source of neuronal and glial progeny, have been
widely interrogated in the last twenty years, mainly to understand their therapeutic potential …

[HTML][HTML] AAV6 mediated Gsx1 expression in neural stem progenitor cells promotes neurogenesis and restores locomotor function after contusion spinal cord injury

Z Finkel, F Esteban, B Rodriguez, T Clifford, A Joseph… - …, 2024 - Elsevier
Genomic screened homeobox 1 (Gsx1 or Gsh1) is a neurogenic transcription factor required
for the generation of excitatory and inhibitory interneurons during spinal cord development …

[HTML][HTML] Transcription factors promote neural regeneration after spinal cord injury

Z Finkel, L Cai - Neural Regeneration Research, 2022 - journals.lww.com
Human spinal cord injury (SCI) results in locomotor and sensory disabilities, which severely
affect the quality of life. To restore function after SCI, it is necessary to repair and reconstruct …

Construction of a searchable database for gene expression changes in spinal cord injury experiments

EC Rouchka, C de Almeida, RB House… - Journal of …, 2024 - liebertpub.com
Spinal cord injury (SCI) is a debilitating condition with an estimated 18,000 new cases
annually in the United States. The field has accepted and adopted standardized databases …

Juxtacrine DLL4-NOTCH1 signaling between astrocytes drives neuroinflammation via the IL-6-STAT3 axis

P Mora, M Laisne, C Bourguignon, P Rouault… - bioRxiv, 2023 - biorxiv.org
Under neuroinflammatory conditions, astrocytes acquire a reactive phenotype that drives
acute inflammatory injury as well as chronic neurodegeneration. We hypothesized that …