Antimalarial drug resistance, in particular resistance to Plasmodium falciparum, challenges
the treatment and control of malaria. In this Review, we summarise evolving patterns of …

Antimalarial drugs are key tools for the control and elimination of malaria. Recent decreases
in the global malaria burden are likely due, in part, to the deployment of artemisinin-based …

Abstract Background In Uganda, artemether-lumefantrine is recommended for malaria
treatment and sulfadoxine-pyrimethamine for chemoprevention during pregnancy, but drug …

In regions with high malaria endemicity, the withdrawal of chloroquine (CQ) as first-line
treatment of Plasmodium falciparum infections has typically led to the restoration of CQ …

The emergence of resistance to artemisinin derivatives in Southeast Asia, manifested as
delayed clearance of Plasmodium falciparum following treatment with artemisinins, is a …

Drug‐resistant parasites repeatedly arise as a result of widespread use of antimalarial drugs
and have contributed significantly to the failure to control and eradicate malaria throughout …

The development of resistance to antimalarials is a major challenge for global malaria
control. Artemisinin-based combination therapies, the newest class of antimalarials, are …

Background Chloroquine, a previous highly efficacious, easy to use and affordable anti-
malarial agent was withdrawn from malaria endemic regions due to high levels of …

Background. In treating malaria in Uganda, artemether-lumefantrine (AL) has been
associated with a lower risk of recurrent parasitemia, compared with artesunate …

Drugs that target the folate‐synthesis pathway have a long history of effectiveness against a
variety of pathogens. As antimalarials, the antifolates were safe and well tolerated, but …