Highlights•MK endomitosis is associated with both a defect in cytokinesis and
karyokinesis.•A myosin II accumulation defect at the furrow induces the cytokinesis …

Colorectal (CRC) and hepatocellular carcinoma (HCC) are associated with chronic
inflammation, which plays a role in tumor development and malignant progression. An …

Megakaryocytes (MKs) are responsible for platelet biogenesis, which is believed to occur
canonically in adult bone marrow (BM) and in the fetal liver during development. However …

Platelets contribute to several types of cancer through plenty of mechanisms. Upon
activation, platelets release many molecules, including growth and angiogenic factors …

A major role for human (h) CXCL8 (interleukin-8) in the pathobiology of myelofibrosis (MF)
has been suggested by observations indicating that MF megakaryocytes express increased …

Platelets, generated from precursor megakaryocytes (MKs), are central mediators of
hemostasis and thrombosis. The process of thrombopoiesis is extremely complex, regulated …

Infantile (fetal and neonatal) megakaryocytes (Mks) have a distinct phenotype consisting of
hyperproliferation, limited morphogenesis, and low platelet production capacity. These …

Inherited thrombocytopenia results in low platelet counts and increased bleeding. Subsets of
these patients have monoallelic germline mutations in ETV6 or RUNX1 and a heightened …

Calreticulin (CALR) mutations are driver mutations in myeloproliferative neoplasms (MPNs),
leading to activation of the thrombopoietin receptor and causing abnormal …

Human pluripotent stem cells (hPSCs) have been suggested as a potential source for the de
novo production of blood cells for transfusion, immunotherapies, and transplantation …