The availability of the human genome sequence and tools for interrogating individual
genomes provide an unprecedented opportunity to apply genetics to medicine. Mendelian …

Mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator
undermine many host defense systems by inhibiting the function of airway-surface liquid …

Cystic fibrosis-related diabetes (CFRD) is the most common comorbidity associated with
cystic fibrosis (CF).[A]• The pathophysiology of CFRD is complex and includes the loss of …

Cystic fibrosis–related (CF-related) diabetes (CFRD) is an increasingly common and
devastating comorbidity of CF, affecting approximately 35% of adults with CF. However, the …

Cystic fibrosis (CF) is a multiorgan disease caused by mutations in the cystic fibrosis
transmembrane conductance regulator (CFTR). In patients with CF, abnormalities initiate in …

The discovery of the Cystic fibrosis (CF) gene in 1989 has paved the way for incredible
progress in treating the disease such that the mean survival age of individuals living with CF …

Over the past 30 years, a range of cystic fibrosis (CF) animal models have been generated
for research purposes. Different species, including mice, rats, ferrets, rabbits, pigs, sheep …

Diabetes mellitus has emerged as a common comorbidity in cystic fibrosis and is considered
a clinical entity (cystic fibrosis-related diabetes, CFRD) distinct from that of type 1 diabetes …

Our understanding of the multiorgan pathology of cystic fibrosis (CF) has improved
impressively during the last decades, but we still lack a full comprehension of the disease …

The pancreas is one of the earliest, and most commonly affected, organs in patients with
cystic fibrosis (CF). Studying the pathogenesis of pancreatic disease is limited in CF …